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Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis
Numerous studies on humans and animals have indicated that the corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) stimulate both individually and synergistically secretion of adrenocorticotropic hormone (ACTH) by corticotropic cells in anterior pituitary. With aim to characterize...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581400/ https://www.ncbi.nlm.nih.gov/pubmed/36277700 http://dx.doi.org/10.3389/fendo.2022.976323 |
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author | Stojiljković, Aleksandra S. Čupić, Željko Maćešić, Stevan Ivanović-Šašić, Ana Kolar-Anić, Ljiljana |
author_facet | Stojiljković, Aleksandra S. Čupić, Željko Maćešić, Stevan Ivanović-Šašić, Ana Kolar-Anić, Ljiljana |
author_sort | Stojiljković, Aleksandra S. |
collection | PubMed |
description | Numerous studies on humans and animals have indicated that the corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) stimulate both individually and synergistically secretion of adrenocorticotropic hormone (ACTH) by corticotropic cells in anterior pituitary. With aim to characterize and better comprehend the mechanisms underlying the effects of AVP on Hypothalamic-Pituitary-Adrenal (HPA) axis ultradian dynamics, AVP is here incorporated into our previously proposed stoichiometric model of HPA axis in humans. This extended nonlinear network reaction model took into account AVP by: reaction steps associated with two separate inflows of AVP into pituitary portal system, that is synthesized and released from hypothalamic parvocellular and magnocellular neuronal populations, as well as summarized reaction steps related to its individual and synergistic action with CRH on corticotropic cells. To explore the properties of extended model and its capacity to emulate the effects of AVP, nonlinear dynamical systems theory and bifurcation analyses based on numerical simulations were utilized to determine the dependence of ultradian oscillations on rate constants of the inflows of CRH and AVP from parvocellular neuronal populations, the conditions under which dynamical transitions occur due to their synergistic action and, moreover, the types of these transitions. The results show that under certain conditions, HPA system could enter into oscillatory dynamic states from stable steady state and vice versa under the influence of synergy reaction rate constant. Transitions between these dynamical states were always through supercritical Andronov-Hopf bifurcation point. Also, results revealed the conditions under which amplitudes of ultradian oscillations could increase several-fold due to CRH and AVP synergistic stimulation of ACTH secretion in accordance with results reported in the literature. Moreover, results showed experimentally observed superiority of CRH as a stimulator of ACTH secretion compared to AVP in humans. The proposed model can be very useful in studies related to the role of AVP and its synergistic action with CRH in life-threatening circumstances such as acute homeostasis dynamic crisis, autoimmune inflammations or severe hypovolemia requiring instant or several-days sustained corticosteroid excess levels. Moreover, the model can be helpful for investigations of indirect AVP-induced HPA activity by exogenously administered AVP used in therapeutic treatment. |
format | Online Article Text |
id | pubmed-9581400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95814002022-10-20 Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis Stojiljković, Aleksandra S. Čupić, Željko Maćešić, Stevan Ivanović-Šašić, Ana Kolar-Anić, Ljiljana Front Endocrinol (Lausanne) Endocrinology Numerous studies on humans and animals have indicated that the corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) stimulate both individually and synergistically secretion of adrenocorticotropic hormone (ACTH) by corticotropic cells in anterior pituitary. With aim to characterize and better comprehend the mechanisms underlying the effects of AVP on Hypothalamic-Pituitary-Adrenal (HPA) axis ultradian dynamics, AVP is here incorporated into our previously proposed stoichiometric model of HPA axis in humans. This extended nonlinear network reaction model took into account AVP by: reaction steps associated with two separate inflows of AVP into pituitary portal system, that is synthesized and released from hypothalamic parvocellular and magnocellular neuronal populations, as well as summarized reaction steps related to its individual and synergistic action with CRH on corticotropic cells. To explore the properties of extended model and its capacity to emulate the effects of AVP, nonlinear dynamical systems theory and bifurcation analyses based on numerical simulations were utilized to determine the dependence of ultradian oscillations on rate constants of the inflows of CRH and AVP from parvocellular neuronal populations, the conditions under which dynamical transitions occur due to their synergistic action and, moreover, the types of these transitions. The results show that under certain conditions, HPA system could enter into oscillatory dynamic states from stable steady state and vice versa under the influence of synergy reaction rate constant. Transitions between these dynamical states were always through supercritical Andronov-Hopf bifurcation point. Also, results revealed the conditions under which amplitudes of ultradian oscillations could increase several-fold due to CRH and AVP synergistic stimulation of ACTH secretion in accordance with results reported in the literature. Moreover, results showed experimentally observed superiority of CRH as a stimulator of ACTH secretion compared to AVP in humans. The proposed model can be very useful in studies related to the role of AVP and its synergistic action with CRH in life-threatening circumstances such as acute homeostasis dynamic crisis, autoimmune inflammations or severe hypovolemia requiring instant or several-days sustained corticosteroid excess levels. Moreover, the model can be helpful for investigations of indirect AVP-induced HPA activity by exogenously administered AVP used in therapeutic treatment. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9581400/ /pubmed/36277700 http://dx.doi.org/10.3389/fendo.2022.976323 Text en Copyright © 2022 Stojiljković, Čupić, Maćešić, Ivanović-Šašić and Kolar-Anić https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Stojiljković, Aleksandra S. Čupić, Željko Maćešić, Stevan Ivanović-Šašić, Ana Kolar-Anić, Ljiljana Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis |
title | Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis |
title_full | Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis |
title_fullStr | Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis |
title_full_unstemmed | Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis |
title_short | Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis |
title_sort | influence of arginine vasopressin on the ultradian dynamics of hypothalamic-pituitary-adrenal axis |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581400/ https://www.ncbi.nlm.nih.gov/pubmed/36277700 http://dx.doi.org/10.3389/fendo.2022.976323 |
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