Disruption of multiple copies of the Prostaglandin F2alpha synthase gene affects oxidative stress response and infectivity in Trypanosoma cruzi

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a serious chronic parasitic disease, currently treated with Nifurtimox (NFX) and Benznidazole (BZ). In addition to high toxicity, these drugs have low healing efficacy, especially in the chronic phase of the disease. The existence of drug...

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Detalles Bibliográficos
Autores principales: Santi, Ana Maria Murta, Ribeiro, Juliana Martins, Reis-Cunha, João Luís, Burle-Caldas, Gabriela de Assis, Santos, Isabella Fernandes Martins, Silva, Paula Alves, Resende, Daniela de Melo, Bartholomeu, Daniella Castanheira, Teixeira, Santuza Maria Ribeiro, Murta, Silvane Maria Fonseca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581433/
https://www.ncbi.nlm.nih.gov/pubmed/36260546
http://dx.doi.org/10.1371/journal.pntd.0010845

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