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Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus
The review presents modern ideas about peripheral microhemodynamics, approaches to the ana-lysis of skin blood flow oscillations and their diagnostic significance. Disorders of skin microhemodynamics in type 2 diabetes mellitus (DM) and the possibility of their interpretation from the standpoint of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pleiades Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581453/ https://www.ncbi.nlm.nih.gov/pubmed/36281313 http://dx.doi.org/10.1134/S0006350922040200 |
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author | Tikhonova, I. V. Grinevich, A. A. Tankanag, A. V. Safronova, V. G. |
author_facet | Tikhonova, I. V. Grinevich, A. A. Tankanag, A. V. Safronova, V. G. |
author_sort | Tikhonova, I. V. |
collection | PubMed |
description | The review presents modern ideas about peripheral microhemodynamics, approaches to the ana-lysis of skin blood flow oscillations and their diagnostic significance. Disorders of skin microhemodynamics in type 2 diabetes mellitus (DM) and the possibility of their interpretation from the standpoint of external and internal interactions between systems of skin blood flow regulation, based on a comparison of couplings in normal and pathological conditions, including models of pathologies on animals, are considered. The factors and mechanisms of vasomotor regulation, among them receptors and signaling events in endothelial and smooth muscle cells considered as models of microvessels are discussed. Attention was drawn to the disturbance of Ca(2+)-dependent regulation of coupling between vascular cells and NO-dependent regulation of vasodilation in diabetes mellitus. The main mechanisms of insulin resistance in type 2 DM are considered to be a defect in the number of insulin receptors and impaired signal transduction from the receptor to phosphatidylinositol-3-kinase and downstream targets. Reactive oxygen species plays an important role in vascular dysfunction in hyperglycemia. It is assumed that the considered molecular and cellular mechanisms of microhemodynamics regulation are involved in the formation of skin blood flow oscillations. Parameters of skin blood microcirculation can be used as diagnostic and prognostic markers for assessing the state of the body. |
format | Online Article Text |
id | pubmed-9581453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Pleiades Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-95814532022-10-20 Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus Tikhonova, I. V. Grinevich, A. A. Tankanag, A. V. Safronova, V. G. Biophysics (Oxf) Complex Systems Biophysics The review presents modern ideas about peripheral microhemodynamics, approaches to the ana-lysis of skin blood flow oscillations and their diagnostic significance. Disorders of skin microhemodynamics in type 2 diabetes mellitus (DM) and the possibility of their interpretation from the standpoint of external and internal interactions between systems of skin blood flow regulation, based on a comparison of couplings in normal and pathological conditions, including models of pathologies on animals, are considered. The factors and mechanisms of vasomotor regulation, among them receptors and signaling events in endothelial and smooth muscle cells considered as models of microvessels are discussed. Attention was drawn to the disturbance of Ca(2+)-dependent regulation of coupling between vascular cells and NO-dependent regulation of vasodilation in diabetes mellitus. The main mechanisms of insulin resistance in type 2 DM are considered to be a defect in the number of insulin receptors and impaired signal transduction from the receptor to phosphatidylinositol-3-kinase and downstream targets. Reactive oxygen species plays an important role in vascular dysfunction in hyperglycemia. It is assumed that the considered molecular and cellular mechanisms of microhemodynamics regulation are involved in the formation of skin blood flow oscillations. Parameters of skin blood microcirculation can be used as diagnostic and prognostic markers for assessing the state of the body. Pleiades Publishing 2022-10-19 2022 /pmc/articles/PMC9581453/ /pubmed/36281313 http://dx.doi.org/10.1134/S0006350922040200 Text en © Pleiades Publishing, Inc. 2022, ISSN 0006-3509, Biophysics, 2022, Vol. 67, No. 4, pp. 647–659. © Pleiades Publishing, Inc., 2022.Russian Text © The Author(s), 2022, published in Biofizika, 2022, Vol. 67, No. 4, pp. 805–818. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Complex Systems Biophysics Tikhonova, I. V. Grinevich, A. A. Tankanag, A. V. Safronova, V. G. Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus |
title | Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus |
title_full | Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus |
title_fullStr | Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus |
title_full_unstemmed | Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus |
title_short | Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus |
title_sort | skin microhemodynamics and mechanisms of its regulation in type 2 diabetes mellitus |
topic | Complex Systems Biophysics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581453/ https://www.ncbi.nlm.nih.gov/pubmed/36281313 http://dx.doi.org/10.1134/S0006350922040200 |
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