RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells

Inhibitory G proteins (GNAI/Gα(i)) bind to the scaffold G protein signaling modulator 2 (GPSM2) to form a conserved polarity complex that regulates cytoskeleton organization. GPSM2 keeps GNAI in a guanosine diphosphate (GDP)-bound state, but how GPSM2-GNAI is generated or relates to heterotrimeric G...

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Detalles Bibliográficos
Autores principales: Akturk, Anil, Day, Matthew, Tarchini, Basile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581478/
https://www.ncbi.nlm.nih.gov/pubmed/36260679
http://dx.doi.org/10.1126/sciadv.abq2826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581478/
https://www.ncbi.nlm.nih.gov/pubmed/36260679
http://dx.doi.org/10.1126/sciadv.abq2826

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