Cargando…

RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells

Inhibitory G proteins (GNAI/Gα(i)) bind to the scaffold G protein signaling modulator 2 (GPSM2) to form a conserved polarity complex that regulates cytoskeleton organization. GPSM2 keeps GNAI in a guanosine diphosphate (GDP)-bound state, but how GPSM2-GNAI is generated or relates to heterotrimeric G...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akturk, Anil, Day, Matthew, Tarchini, Basile
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581478/ https://www.ncbi.nlm.nih.gov/pubmed/36260679 http://dx.doi.org/10.1126/sciadv.abq2826

Ejemplares similares

Promotion of row 1–specific tip complex condensates by Gpsm2-Gαi provides insights into row identity of the tallest stereocilia
por: Shi, Yingdong, et al.
Publicado: (2022)

Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia
por: Gong, Rui, et al.
Publicado: (2022)

Mechanical stimulation of human hair follicle outer root sheath cultures activates adjacent sensory neurons
por: Agramunt, Julià, et al.
Publicado: (2023)

CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation
por: Qiu, Min, et al.
Publicado: (2023)

Polarized condensates confer row identity of hair cell stereocilia
por: Shi, Yingdong, et al.
Publicado: (2022)

EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia
por: Kindt, Katie S., et al.
Publicado: (2021)

Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells
por: Das, Jugal Kishore, et al.
Publicado: (2022)

The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma
por: Wang, Donghai, et al.
Publicado: (2023)

The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats
por: Huda, Armela, et al.
Publicado: (2023)

Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase
por: Piserchio, Andrea, et al.
Publicado: (2022)

Auxin promotes hypocotyl elongation by enhancing BZR1 nuclear accumulation in Arabidopsis
por: Yu, Zipeng, et al.
Publicado: (2023)

Aclarubicin stimulates RNA polymerase II elongation at closely spaced divergent promoters
por: Wooten, Matthew, et al.
Publicado: (2023)

Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation
por: Hochheiser, Inga V., et al.
Publicado: (2022)

COP1 dynamics integrate conflicting seasonal light and thermal cues in the control of Arabidopsis elongation
por: Nieto, Cristina, et al.
Publicado: (2022)

Pointed-end processive elongation of actin filaments by Vibrio effectors VopF and VopL
por: Kudryashova, Elena, et al.
Publicado: (2022)

Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction
por: Kageyama, Tatsuto, et al.
Publicado: (2022)

Incorporation of hair follicles in 3D bioprinted models of human skin
por: Motter Catarino, Carolina, et al.
Publicado: (2023)

Varying mechanical forces drive sensory epithelium formation
por: Xia, Mingyu, et al.
Publicado: (2023)

ELOA3: A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster
por: Morgan, Marc A. J., et al.
Publicado: (2023)

Variations in Gnai2 and Rgs1 Expression Affect Chemokine Receptor Signaling and the Organization of Secondary Lymphoid Organs
por: Hwang, II-Young, et al.
Publicado: (2010)

Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea
por: Li, Xiao-Jun, et al.
Publicado: (2022)

Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism
por: Wang, Gaofeng, et al.
Publicado: (2023)

Dynamic instability of dendrite tips generates the highly branched morphologies of sensory neurons
por: Shree, Sonal, et al.
Publicado: (2022)

Defective Gpsm2/Gα(i3) signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome
por: Mauriac, Stephanie A., et al.
Publicado: (2017)

Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C
por: Soliman, Shimaa H. A., et al.
Publicado: (2023)

Lactate supports a metabolic-epigenetic link in macrophage polarization
por: Noe, Jordan T., et al.
Publicado: (2021)

Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis
por: Guan, Chunmei, et al.
Publicado: (2022)

The biosynthetic-secretory pathway, supplemented by recycling routes, determines epithelial membrane polarity
por: Zhang, Nan, et al.
Publicado: (2023)

Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles
por: Siletti, Kimberly, et al.
Publicado: (2017)

Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex
por: Ban, Yue, et al.
Publicado: (2021)

Branched-chain actin dynamics polarizes vesicle trajectories and partitions apicobasal epithelial membrane domains
por: Jafari, Gholamali, et al.
Publicado: (2023)

The organization of actin filaments in the stereocilia of cochlear hair cells
Publicado: (1980)

Inner hair cell stereocilia are embedded in the tectorial membrane
por: Hakizimana, Pierre, et al.
Publicado: (2021)

Radixin modulates the function of outer hair cell stereocilia
por: Prasad, Sonal, et al.
Publicado: (2020)

Control of stereocilia length during development of hair bundles
por: Krey, Jocelyn F., et al.
Publicado: (2023)

Coevolution of the Ess1-CTD axis in polar fungi suggests a role for phase separation in cold tolerance
por: Palumbo, Ryan J., et al.
Publicado: (2022)

Author Correction: Defective Gpsm2/Gα(i3) signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome
por: Mauriac, Stephanie A., et al.
Publicado: (2018)

Actin filaments, stereocilia, and hair cells of the bird cochlea. I. Length, number, width, and distribution of stereocilia of each hair cell are related to the position of the hair cell on the cochlea
Publicado: (1983)

Actin filaments, stereocilia, and hair cells of the bird cochlea. II. Packing of actin filaments in the stereocilia and in the cuticular plate and what happens to the organization when the stereocilia are bent
Publicado: (1983)

Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions
por: Hildenbrand, Karen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_28qqg399adudttdjsc5gruirdp