Cargando…
Oxysterol misbalance critically contributes to Wilson disease pathogenesis
Wilson disease (WD) is a metabolic disorder caused by inactivation of the copper-transporting ATPase 2 (ATP7B) and copper (Cu) overload in tissues. Excess Cu causes oxidative stress and pathologic changes with poorly understood mechanistic connections. In Atp7b(−/−) mice with established liver disea...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581482/ https://www.ncbi.nlm.nih.gov/pubmed/36260680 http://dx.doi.org/10.1126/sciadv.adc9022 |