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Oxysterol misbalance critically contributes to Wilson disease pathogenesis

Wilson disease (WD) is a metabolic disorder caused by inactivation of the copper-transporting ATPase 2 (ATP7B) and copper (Cu) overload in tissues. Excess Cu causes oxidative stress and pathologic changes with poorly understood mechanistic connections. In Atp7b(−/−) mice with established liver disea...

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Detalles Bibliográficos
Autores principales:	Dev, Som, Muchenditsi, Abigael, Gottlieb, Aline, Deme, Pragney, Murphy, Sean, Gabrielson, Kathleen L., Dong, Yixuan, Hughes, Robert, Haughey, Norman J., Hamilton, James P., Lutsenko, Svetlana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581482/ https://www.ncbi.nlm.nih.gov/pubmed/36260680 http://dx.doi.org/10.1126/sciadv.adc9022

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