Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models

Accumulation of the microtubule-associated protein Tau is linked to neuronal cell death in tauopathies, but how intraneuronal Tau levels are regulated in health and disease remains unclear. Here, we show that conditional inactivation of the trafficking adaptor protein Numb in retinal ganglion cells...

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Detalles Bibliográficos
Autores principales: Lacomme, Marine, Hales, Sarah C., Brown, Thomas W., Stevanovic, Katarina, Jolicoeur, Christine, Cai, Jenny, Bois, Therence, Desrosiers, Melissa, Dalkara, Deniz, Cayouette, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581485/
https://www.ncbi.nlm.nih.gov/pubmed/36260685
http://dx.doi.org/10.1126/sciadv.abm4295

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