Myocardial Injury and Altered Gene Expression Associated With SARS-CoV-2 Infection or mRNA Vaccination

SARS CoV-2 enters host cells via its Spike protein moiety binding to the essential cardiac enzyme angiotensin-converting enzyme (ACE) 2, followed by internalization. COVID-19 mRNA vaccines are RNA sequences that are translated into Spike protein, which follows the same ACE2-binding route as the inta...

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Detalles Bibliográficos
Autores principales: Altman, Natasha L., Berning, Amber A., Saxon, Cara E., Adamek, Kylie E., Wagner, Jessica A., Slavov, Dobromir, Quaife, Robert A., Gill, Edward A., Minobe, Wayne A., Jonas, Eric R., Carroll, Ian A., Huebler, Sophia P., Raines, Joshua, Messenger, John C., Ambardekar, Amrut V., Mestroni, Luisa, Rosenberg, Rachel M., Rove, Jessica, Campbell, Thomas B., Bristow, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581498/
https://www.ncbi.nlm.nih.gov/pubmed/36281440
http://dx.doi.org/10.1016/j.jacbts.2022.08.005
Descripción
Sumario:SARS CoV-2 enters host cells via its Spike protein moiety binding to the essential cardiac enzyme angiotensin-converting enzyme (ACE) 2, followed by internalization. COVID-19 mRNA vaccines are RNA sequences that are translated into Spike protein, which follows the same ACE2-binding route as the intact virion. In model systems, isolated Spike protein can produce cell damage and altered gene expression, and myocardial injury or myocarditis can occur during COVID-19 or after mRNA vaccination. We investigated 7 COVID-19 and 6 post–mRNA vaccination patients with myocardial injury and found nearly identical alterations in gene expression that would predispose to inflammation, coagulopathy, and myocardial dysfunction.

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