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Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports
Peripheral facial paralysis (PFP) has been shown to be a neurological manifestation of COVID-19. The current study presents two cases of PFP after COVID-19, along with a rapid review of known cases in the literature. Both case reports were conducted following CARE guidelines. We also performed a sys...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581522/ https://www.ncbi.nlm.nih.gov/pubmed/36305011 http://dx.doi.org/10.1590/1678-9199-JVATITD-2022-0020 |
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author | Cavalcante, Thalitta Mendes Gubert, Vanessa Terezinha Lima, Carolina de Deus Luciano, Larissa Anjos Croda, Mariana Garcia Venturini, James Gasparoto, Antonio Luiz Dal Bello Santiago, Wellyngton Matheus Souza Motta-Castro, Ana Rita Coimbra Reis, Fernanda Paes Marques, Ana Paula da Costa Lorenz, Aline Pedroso Fava, Wellington Santos Zardin, Marina Castilhos Souza Umaki Chaves, Cláudia Elizabeth Volpe Braga, Gabriel Pereira Paniago, Anamaria Mello Miranda de Oliveira, Sandra Maria do Valle Leone |
author_facet | Cavalcante, Thalitta Mendes Gubert, Vanessa Terezinha Lima, Carolina de Deus Luciano, Larissa Anjos Croda, Mariana Garcia Venturini, James Gasparoto, Antonio Luiz Dal Bello Santiago, Wellyngton Matheus Souza Motta-Castro, Ana Rita Coimbra Reis, Fernanda Paes Marques, Ana Paula da Costa Lorenz, Aline Pedroso Fava, Wellington Santos Zardin, Marina Castilhos Souza Umaki Chaves, Cláudia Elizabeth Volpe Braga, Gabriel Pereira Paniago, Anamaria Mello Miranda de Oliveira, Sandra Maria do Valle Leone |
author_sort | Cavalcante, Thalitta Mendes |
collection | PubMed |
description | Peripheral facial paralysis (PFP) has been shown to be a neurological manifestation of COVID-19. The current study presents two cases of PFP after COVID-19, along with a rapid review of known cases in the literature. Both case reports were conducted following CARE guidelines. We also performed a systematic review of PFP cases temporally related to COVID-19 using PubMed, Embase, and Cochrane Library databases on August 30, 2021, using a rapid review methodology. The two patients experienced PFP 102 and 110 days after COVID-19 symptom onset. SARS-CoV-2 RNA was detected in nasal samples through reverse-transcription real-time polymerase chain reaction (RT-qPCR) testing. Anosmia was the only other neurological manifestation. PFP was treated with steroids in both cases, with complete subsequent recovery. In the rapid review, we identified 764 articles and included 43 studies. From those, 128 patients with PFP were analyzed, of whom 42.1% (54/128) were male, 39.06% (50/128) female, and in 23 cases the gender was not reported. The age range was 18 to 59 (54.68%). The median time between COVID-19 and PFP was three days (ranging from the first symptom of COVID-19 to 40 days after the acute phase of infection). Late PFP associated with COVID-19 presents mild symptoms and improves with time, with no identified predictors. Late PFP should be added to the spectrum of neurological manifestations associated with the long-term effects of SARS-CoV-2 infection as a post COVID-19 condition. |
format | Online Article Text |
id | pubmed-9581522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
record_format | MEDLINE/PubMed |
spelling | pubmed-95815222022-10-26 Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports Cavalcante, Thalitta Mendes Gubert, Vanessa Terezinha Lima, Carolina de Deus Luciano, Larissa Anjos Croda, Mariana Garcia Venturini, James Gasparoto, Antonio Luiz Dal Bello Santiago, Wellyngton Matheus Souza Motta-Castro, Ana Rita Coimbra Reis, Fernanda Paes Marques, Ana Paula da Costa Lorenz, Aline Pedroso Fava, Wellington Santos Zardin, Marina Castilhos Souza Umaki Chaves, Cláudia Elizabeth Volpe Braga, Gabriel Pereira Paniago, Anamaria Mello Miranda de Oliveira, Sandra Maria do Valle Leone J Venom Anim Toxins Incl Trop Dis Review Peripheral facial paralysis (PFP) has been shown to be a neurological manifestation of COVID-19. The current study presents two cases of PFP after COVID-19, along with a rapid review of known cases in the literature. Both case reports were conducted following CARE guidelines. We also performed a systematic review of PFP cases temporally related to COVID-19 using PubMed, Embase, and Cochrane Library databases on August 30, 2021, using a rapid review methodology. The two patients experienced PFP 102 and 110 days after COVID-19 symptom onset. SARS-CoV-2 RNA was detected in nasal samples through reverse-transcription real-time polymerase chain reaction (RT-qPCR) testing. Anosmia was the only other neurological manifestation. PFP was treated with steroids in both cases, with complete subsequent recovery. In the rapid review, we identified 764 articles and included 43 studies. From those, 128 patients with PFP were analyzed, of whom 42.1% (54/128) were male, 39.06% (50/128) female, and in 23 cases the gender was not reported. The age range was 18 to 59 (54.68%). The median time between COVID-19 and PFP was three days (ranging from the first symptom of COVID-19 to 40 days after the acute phase of infection). Late PFP associated with COVID-19 presents mild symptoms and improves with time, with no identified predictors. Late PFP should be added to the spectrum of neurological manifestations associated with the long-term effects of SARS-CoV-2 infection as a post COVID-19 condition. Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) 2022-10-17 /pmc/articles/PMC9581522/ /pubmed/36305011 http://dx.doi.org/10.1590/1678-9199-JVATITD-2022-0020 Text en https://creativecommons.org/licenses/by/4.0/© The Author(s). 2022 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Cavalcante, Thalitta Mendes Gubert, Vanessa Terezinha Lima, Carolina de Deus Luciano, Larissa Anjos Croda, Mariana Garcia Venturini, James Gasparoto, Antonio Luiz Dal Bello Santiago, Wellyngton Matheus Souza Motta-Castro, Ana Rita Coimbra Reis, Fernanda Paes Marques, Ana Paula da Costa Lorenz, Aline Pedroso Fava, Wellington Santos Zardin, Marina Castilhos Souza Umaki Chaves, Cláudia Elizabeth Volpe Braga, Gabriel Pereira Paniago, Anamaria Mello Miranda de Oliveira, Sandra Maria do Valle Leone Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports |
title | Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports |
title_full | Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports |
title_fullStr | Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports |
title_full_unstemmed | Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports |
title_short | Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports |
title_sort | late peripheral facial paralysis after covid-19: a rapid systematic review and two case reports |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581522/ https://www.ncbi.nlm.nih.gov/pubmed/36305011 http://dx.doi.org/10.1590/1678-9199-JVATITD-2022-0020 |
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