The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes

During the development of humoral immunity, activated B lymphocytes undergo vigorous proliferative, transcriptional, metabolic, and DNA remodeling activities; hence, their genomes are constantly exposed to an onslaught of genotoxic agents and processes. Branched DNA intermediates generated during re...

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Detalles Bibliográficos
Autores principales: Fernandez, Keith Conrad, Feeney, Laura, Smolkin, Ryan M, Yen, Wei-Feng, Matthews, Allysia J, Alread, William, Petrini, John HJ, Chaudhuri, Jayanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581529/
https://www.ncbi.nlm.nih.gov/pubmed/36190107
http://dx.doi.org/10.7554/eLife.77073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581529/
https://www.ncbi.nlm.nih.gov/pubmed/36190107
http://dx.doi.org/10.7554/eLife.77073

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