Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol

PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4 as a cargo receptor that facilitates PCSK9 secretion in HEK293T cells (...

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Detalles Bibliográficos
Autores principales: Tang, Vi T, McCormick, Joseph, Xu, Bolin, Wang, Yawei, Fang, Huan, Wang, Xiao, Siemieniak, David, Khoriaty, Rami, Emmer, Brian T, Chen, Xiao-Wei, Ginsburg, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581532/
https://www.ncbi.nlm.nih.gov/pubmed/36193893
http://dx.doi.org/10.7554/eLife.82269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581532/
https://www.ncbi.nlm.nih.gov/pubmed/36193893
http://dx.doi.org/10.7554/eLife.82269

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