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A Pan-Cancer Analysis of the Role of PBRM1 in Human Tumors

To understand common but distinctive systems to drive oncogenic stages in human tumors is critical for understanding disease programme and developing novel therapeutic strategies. PBRM1 is a critical gene in oncogenesis. We found that PBRM1 is upregulated in multiple cancer genes. Prognostic analyse...

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Autores principales: Liu, Jin, Xie, Xiaoli, Xue, Min, Wang, Jianqing, Chen, Qian, Zhao, Zhen, Sheng, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581638/
https://www.ncbi.nlm.nih.gov/pubmed/36277039
http://dx.doi.org/10.1155/2022/7676541
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author Liu, Jin
Xie, Xiaoli
Xue, Min
Wang, Jianqing
Chen, Qian
Zhao, Zhen
Sheng, Xia
author_facet Liu, Jin
Xie, Xiaoli
Xue, Min
Wang, Jianqing
Chen, Qian
Zhao, Zhen
Sheng, Xia
author_sort Liu, Jin
collection PubMed
description To understand common but distinctive systems to drive oncogenic stages in human tumors is critical for understanding disease programme and developing novel therapeutic strategies. PBRM1 is a critical gene in oncogenesis. We found that PBRM1 is upregulated in multiple cancer genes. Prognostic analyses indicated that higher PBRM1 showed better disease outcomes of head and neck squamous cell carcinoma (HNSC), KIRC, and UCEC, while poorer outcomes in KICH, skin cutaneous melanoma (SKCM), and esophageal carcinoma (ESCA). PBRM1 mutation was most frequent in renal cell carcinoma and showed better disease outcomes of pan-cancer. We also discovered that PBRM1 performance was associated with endothelial cell invasion status in COAD, HNSC, KIRC, LUAD, LUSC, OV, and PAAD, and cancer-related fibroblast invasion was observed in COAD, HNSC, KIRC, LUSC, MESO, OV, and PAAD. We also make the comparison of PBRM1's phosphorylation between normal and basic tumor systems as well as explore potential systems with distinctive functions in PBRM1-mediated oncogenesis. The analysis of pan-cancer offers us an outline of PBRM1's functions in various human cancers, which could promote a comprehensive understanding of PBRM1 in tumorigenesis.
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spelling pubmed-95816382022-10-20 A Pan-Cancer Analysis of the Role of PBRM1 in Human Tumors Liu, Jin Xie, Xiaoli Xue, Min Wang, Jianqing Chen, Qian Zhao, Zhen Sheng, Xia Stem Cells Int Research Article To understand common but distinctive systems to drive oncogenic stages in human tumors is critical for understanding disease programme and developing novel therapeutic strategies. PBRM1 is a critical gene in oncogenesis. We found that PBRM1 is upregulated in multiple cancer genes. Prognostic analyses indicated that higher PBRM1 showed better disease outcomes of head and neck squamous cell carcinoma (HNSC), KIRC, and UCEC, while poorer outcomes in KICH, skin cutaneous melanoma (SKCM), and esophageal carcinoma (ESCA). PBRM1 mutation was most frequent in renal cell carcinoma and showed better disease outcomes of pan-cancer. We also discovered that PBRM1 performance was associated with endothelial cell invasion status in COAD, HNSC, KIRC, LUAD, LUSC, OV, and PAAD, and cancer-related fibroblast invasion was observed in COAD, HNSC, KIRC, LUSC, MESO, OV, and PAAD. We also make the comparison of PBRM1's phosphorylation between normal and basic tumor systems as well as explore potential systems with distinctive functions in PBRM1-mediated oncogenesis. The analysis of pan-cancer offers us an outline of PBRM1's functions in various human cancers, which could promote a comprehensive understanding of PBRM1 in tumorigenesis. Hindawi 2022-10-12 /pmc/articles/PMC9581638/ /pubmed/36277039 http://dx.doi.org/10.1155/2022/7676541 Text en Copyright © 2022 Jin Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Jin
Xie, Xiaoli
Xue, Min
Wang, Jianqing
Chen, Qian
Zhao, Zhen
Sheng, Xia
A Pan-Cancer Analysis of the Role of PBRM1 in Human Tumors
title A Pan-Cancer Analysis of the Role of PBRM1 in Human Tumors
title_full A Pan-Cancer Analysis of the Role of PBRM1 in Human Tumors
title_fullStr A Pan-Cancer Analysis of the Role of PBRM1 in Human Tumors
title_full_unstemmed A Pan-Cancer Analysis of the Role of PBRM1 in Human Tumors
title_short A Pan-Cancer Analysis of the Role of PBRM1 in Human Tumors
title_sort pan-cancer analysis of the role of pbrm1 in human tumors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581638/
https://www.ncbi.nlm.nih.gov/pubmed/36277039
http://dx.doi.org/10.1155/2022/7676541
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