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The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study

BACKGROUND: Several vaccines have been approved against COVID-19, and 5 have been used in Indonesia. Due to the decrease in antibody levels 3 to 6 months after the second dose of CoronaVac, healthcare workers received the third booster of mRNA vaccine (mRNA-1273) to increase the antibody level. This...

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Autores principales: Widysanto, Allen, Prasetya, Ignatius Bima, Meriyanti, Tandry, Sungono, Veli, Setiawan, Diane Lukito, Gunawan, Edy, Adiputra, Bayu, Lorens, Jane Olivia, Santi, Theresia, Pradhana, Cindy Meidy Leony, Yusuf, Irawan, Gunawan, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of Tsinghua University Press. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581641/
https://www.ncbi.nlm.nih.gov/pubmed/38013914
http://dx.doi.org/10.1016/j.imj.2022.10.001
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author Widysanto, Allen
Prasetya, Ignatius Bima
Meriyanti, Tandry
Sungono, Veli
Setiawan, Diane Lukito
Gunawan, Edy
Adiputra, Bayu
Lorens, Jane Olivia
Santi, Theresia
Pradhana, Cindy Meidy Leony
Yusuf, Irawan
Gunawan, Catherine
author_facet Widysanto, Allen
Prasetya, Ignatius Bima
Meriyanti, Tandry
Sungono, Veli
Setiawan, Diane Lukito
Gunawan, Edy
Adiputra, Bayu
Lorens, Jane Olivia
Santi, Theresia
Pradhana, Cindy Meidy Leony
Yusuf, Irawan
Gunawan, Catherine
author_sort Widysanto, Allen
collection PubMed
description BACKGROUND: Several vaccines have been approved against COVID-19, and 5 have been used in Indonesia. Due to the decrease in antibody levels 3 to 6 months after the second dose of CoronaVac, healthcare workers received the third booster of mRNA vaccine (mRNA-1273) to increase the antibody level. This study aimed to evaluate the risk factors of anti-S-RBD IgG levels differences in healthcare workers. METHODS: This study is a retrospective cohort study of 576 healthcare workers without previous SARS-CoV-2 infection who received 2 doses of CoronaVac and the third dose of mRNA-1273 6 months after the second dose. Blood samples were obtained 2nd, 6th, 12th, and 24th weeks after the second dose of CoronaVac vaccine administration, with mRNA-1273 booster on week 20. Quantitative measurements of IgG antibodies were performed with Elecsys Anti-SARS-CoV-2 S immunoassay. We identify the baseline factors predicting post-vaccination antibody titers using univariate and multivariate linear regression analysis. RESULTS: This study comprised 576 participants aged 32 years old, 72.05% female, and 45.84% from high-risk occupation subgroups. The median antibodies titer level on the 2nd, 6th, 12th, and 24th weeks after the second vaccine dose administration were 40.99 u/mL, 42.01 u/mL, 54.78 u/mL, and 23,225 u/mL. Antibody levels trended highest in female and younger age group (20-29 years old). CONCLUSIONS: The third dose of vaccine increased the quantitative SARS-CoV-2 spike IgG antibody titers and eliminated differences in antibodies titer by gender.
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spelling pubmed-95816412022-10-20 The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study Widysanto, Allen Prasetya, Ignatius Bima Meriyanti, Tandry Sungono, Veli Setiawan, Diane Lukito Gunawan, Edy Adiputra, Bayu Lorens, Jane Olivia Santi, Theresia Pradhana, Cindy Meidy Leony Yusuf, Irawan Gunawan, Catherine Infectious Medicine Original Article BACKGROUND: Several vaccines have been approved against COVID-19, and 5 have been used in Indonesia. Due to the decrease in antibody levels 3 to 6 months after the second dose of CoronaVac, healthcare workers received the third booster of mRNA vaccine (mRNA-1273) to increase the antibody level. This study aimed to evaluate the risk factors of anti-S-RBD IgG levels differences in healthcare workers. METHODS: This study is a retrospective cohort study of 576 healthcare workers without previous SARS-CoV-2 infection who received 2 doses of CoronaVac and the third dose of mRNA-1273 6 months after the second dose. Blood samples were obtained 2nd, 6th, 12th, and 24th weeks after the second dose of CoronaVac vaccine administration, with mRNA-1273 booster on week 20. Quantitative measurements of IgG antibodies were performed with Elecsys Anti-SARS-CoV-2 S immunoassay. We identify the baseline factors predicting post-vaccination antibody titers using univariate and multivariate linear regression analysis. RESULTS: This study comprised 576 participants aged 32 years old, 72.05% female, and 45.84% from high-risk occupation subgroups. The median antibodies titer level on the 2nd, 6th, 12th, and 24th weeks after the second vaccine dose administration were 40.99 u/mL, 42.01 u/mL, 54.78 u/mL, and 23,225 u/mL. Antibody levels trended highest in female and younger age group (20-29 years old). CONCLUSIONS: The third dose of vaccine increased the quantitative SARS-CoV-2 spike IgG antibody titers and eliminated differences in antibodies titer by gender. The Author(s). Published by Elsevier Ltd on behalf of Tsinghua University Press. 2022-12 2022-10-20 /pmc/articles/PMC9581641/ /pubmed/38013914 http://dx.doi.org/10.1016/j.imj.2022.10.001 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Widysanto, Allen
Prasetya, Ignatius Bima
Meriyanti, Tandry
Sungono, Veli
Setiawan, Diane Lukito
Gunawan, Edy
Adiputra, Bayu
Lorens, Jane Olivia
Santi, Theresia
Pradhana, Cindy Meidy Leony
Yusuf, Irawan
Gunawan, Catherine
The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study
title The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study
title_full The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study
title_fullStr The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study
title_full_unstemmed The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study
title_short The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study
title_sort risk factors of sars-cov-2 antibody level differences in healthcare workers post vaccination in siloam hospitals: a nationwide multicenter study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581641/
https://www.ncbi.nlm.nih.gov/pubmed/38013914
http://dx.doi.org/10.1016/j.imj.2022.10.001
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