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Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA

RNA-guided systems, such as CRISPR–Cas, combine programmable substrate recognition with enzymatic function, a combination that has been used advantageously to develop powerful molecular technologies(1,2). Structural studies of these systems have illuminated how the RNA and protein jointly recognize...

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Detalles Bibliográficos
Autores principales:	Hirano, Seiichi, Kappel, Kalli, Altae-Tran, Han, Faure, Guilhem, Wilkinson, Max E., Kannan, Soumya, Demircioglu, F. Esra, Yan, Rui, Shiozaki, Momoko, Yu, Zhiheng, Makarova, Kira S., Koonin, Eugene V., Macrae, Rhiannon K., Zhang, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581776/ https://www.ncbi.nlm.nih.gov/pubmed/36224386 http://dx.doi.org/10.1038/s41586-022-05324-6

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