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Comparison of [(18)F]fluciclovine and [(18)F]FDG PET/CT in Newly Diagnosed Multiple Myeloma Patients
PURPOSE: [(18)F]FDG PET/CT in multiple myeloma (MM) is currently the best technology to demonstrate patchy and extramedullary disease. However, [(18)F]FDG PET has some limitations, and imaging with alternative tracers should be explored. In this study, we aimed to evaluate the performance of [(18)F]...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581841/ https://www.ncbi.nlm.nih.gov/pubmed/35501622 http://dx.doi.org/10.1007/s11307-022-01734-0 |
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author | Stokke, Caroline Nørgaard, Jakob Nordberg Feiring Phillips, Hilde Sherwani, Alexander Nuruddin, Syed Connelly, James Schjesvold, Fredrik Revheim, Mona-Elisabeth |
author_facet | Stokke, Caroline Nørgaard, Jakob Nordberg Feiring Phillips, Hilde Sherwani, Alexander Nuruddin, Syed Connelly, James Schjesvold, Fredrik Revheim, Mona-Elisabeth |
author_sort | Stokke, Caroline |
collection | PubMed |
description | PURPOSE: [(18)F]FDG PET/CT in multiple myeloma (MM) is currently the best technology to demonstrate patchy and extramedullary disease. However, [(18)F]FDG PET has some limitations, and imaging with alternative tracers should be explored. In this study, we aimed to evaluate the performance of [(18)F]fluciclovine PET compared to [(18)F]FDG PET in newly diagnosed MM patients. PROCEDURES: Thirteen newly diagnosed transplant eligible MM patients were imaged both with [(18)F]FDG PET/CT and [(18)F]fluciclovine PET/CT within 1 week in a prospective study. The subjects were visually assessed positive or negative for disease. The number of lesions and the SUV(max) of selected lesions were measured for both tracers. Furthermore, tracer uptake ratios were obtained by dividing lesion SUV(max) by blood or bone marrow SUV(max). Between-group differences and correlations were assessed with paired t-tests and Pearson tests. Bone marrow SUVs were compared to bone marrow plasma cell percentage in biopsy samples. RESULTS: Nine subjects were assessed positively by [(18)F]FDG PET (69%) and 12 positives by [(18)F]fluciclovine PET (92%). All positive subjects had [(18)F]fluciclovine scans that were qualitatively scored as easier to interpret visually than the [(18)F]FDG scans. The number of lesions was also higher; seven of nine subjects with distinct hot spots on [(18)F]fluciclovine PET had fewer or no visible lesions on [(18)F]FDG PET. The mean lesion SUV(max) values were 8.2 and 3.8 for [(18)F]fluciclovine and [(18)F]FDG, respectively. The mean tumour to blood values were 6.4 and 2.0 for [(18)F]fluciclovine and [(18)F]FDG, and the mean ratios between tumour and bone marrow were 2.1 and 1.5 for [(18)F]fluciclovine and [(18)F]FDG. The lesion SUV(max) and ratios were significantly higher for [(18)F]fluciclovine (all p < 0.01). Local [(18)F]fluciclovine SUV(max) or SUV(mean) values in os ilium and the percentage of plasma cells in bone marrow biopsies were linearly correlated (p = 0.048). There were no significant correlations between [(18)F]FDG SUVs and plasma cells (p = 0.82). CONCLUSIONS: Based on this pilot study, [(18)F]fluciclovine is a promising tracer for MM. The visual and semi-quantitative evaluations indicate that [(18)F]fluciclovine PET/CT can out-perform [(18)F]FDG PET/CT at diagnosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11307-022-01734-0. |
format | Online Article Text |
id | pubmed-9581841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-95818412022-10-21 Comparison of [(18)F]fluciclovine and [(18)F]FDG PET/CT in Newly Diagnosed Multiple Myeloma Patients Stokke, Caroline Nørgaard, Jakob Nordberg Feiring Phillips, Hilde Sherwani, Alexander Nuruddin, Syed Connelly, James Schjesvold, Fredrik Revheim, Mona-Elisabeth Mol Imaging Biol Research Article PURPOSE: [(18)F]FDG PET/CT in multiple myeloma (MM) is currently the best technology to demonstrate patchy and extramedullary disease. However, [(18)F]FDG PET has some limitations, and imaging with alternative tracers should be explored. In this study, we aimed to evaluate the performance of [(18)F]fluciclovine PET compared to [(18)F]FDG PET in newly diagnosed MM patients. PROCEDURES: Thirteen newly diagnosed transplant eligible MM patients were imaged both with [(18)F]FDG PET/CT and [(18)F]fluciclovine PET/CT within 1 week in a prospective study. The subjects were visually assessed positive or negative for disease. The number of lesions and the SUV(max) of selected lesions were measured for both tracers. Furthermore, tracer uptake ratios were obtained by dividing lesion SUV(max) by blood or bone marrow SUV(max). Between-group differences and correlations were assessed with paired t-tests and Pearson tests. Bone marrow SUVs were compared to bone marrow plasma cell percentage in biopsy samples. RESULTS: Nine subjects were assessed positively by [(18)F]FDG PET (69%) and 12 positives by [(18)F]fluciclovine PET (92%). All positive subjects had [(18)F]fluciclovine scans that were qualitatively scored as easier to interpret visually than the [(18)F]FDG scans. The number of lesions was also higher; seven of nine subjects with distinct hot spots on [(18)F]fluciclovine PET had fewer or no visible lesions on [(18)F]FDG PET. The mean lesion SUV(max) values were 8.2 and 3.8 for [(18)F]fluciclovine and [(18)F]FDG, respectively. The mean tumour to blood values were 6.4 and 2.0 for [(18)F]fluciclovine and [(18)F]FDG, and the mean ratios between tumour and bone marrow were 2.1 and 1.5 for [(18)F]fluciclovine and [(18)F]FDG. The lesion SUV(max) and ratios were significantly higher for [(18)F]fluciclovine (all p < 0.01). Local [(18)F]fluciclovine SUV(max) or SUV(mean) values in os ilium and the percentage of plasma cells in bone marrow biopsies were linearly correlated (p = 0.048). There were no significant correlations between [(18)F]FDG SUVs and plasma cells (p = 0.82). CONCLUSIONS: Based on this pilot study, [(18)F]fluciclovine is a promising tracer for MM. The visual and semi-quantitative evaluations indicate that [(18)F]fluciclovine PET/CT can out-perform [(18)F]FDG PET/CT at diagnosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11307-022-01734-0. Springer International Publishing 2022-05-02 2022 /pmc/articles/PMC9581841/ /pubmed/35501622 http://dx.doi.org/10.1007/s11307-022-01734-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Stokke, Caroline Nørgaard, Jakob Nordberg Feiring Phillips, Hilde Sherwani, Alexander Nuruddin, Syed Connelly, James Schjesvold, Fredrik Revheim, Mona-Elisabeth Comparison of [(18)F]fluciclovine and [(18)F]FDG PET/CT in Newly Diagnosed Multiple Myeloma Patients |
title | Comparison of [(18)F]fluciclovine and [(18)F]FDG PET/CT in Newly Diagnosed Multiple Myeloma Patients |
title_full | Comparison of [(18)F]fluciclovine and [(18)F]FDG PET/CT in Newly Diagnosed Multiple Myeloma Patients |
title_fullStr | Comparison of [(18)F]fluciclovine and [(18)F]FDG PET/CT in Newly Diagnosed Multiple Myeloma Patients |
title_full_unstemmed | Comparison of [(18)F]fluciclovine and [(18)F]FDG PET/CT in Newly Diagnosed Multiple Myeloma Patients |
title_short | Comparison of [(18)F]fluciclovine and [(18)F]FDG PET/CT in Newly Diagnosed Multiple Myeloma Patients |
title_sort | comparison of [(18)f]fluciclovine and [(18)f]fdg pet/ct in newly diagnosed multiple myeloma patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581841/ https://www.ncbi.nlm.nih.gov/pubmed/35501622 http://dx.doi.org/10.1007/s11307-022-01734-0 |
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