Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development

The Runt-related transcription factor (Runx) family plays various roles in the homeostasis of cartilage. Here, we examined the role of Runx2 and Runx3 for osteoarthritis development in vivo and in vitro. Runx3-knockout mice exhibited accelerated osteoarthritis following surgical induction, accompani...

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Detalles Bibliográficos
Autores principales: Nagata, Kosei, Hojo, Hironori, Chang, Song Ho, Okada, Hiroyuki, Yano, Fumiko, Chijimatsu, Ryota, Omata, Yasunori, Mori, Daisuke, Makii, Yuma, Kawata, Manabu, Kaneko, Taizo, Iwanaga, Yasuhide, Nakamoto, Hideki, Maenohara, Yuji, Tachibana, Naohiro, Ishikura, Hisatoshi, Higuchi, Junya, Taniguchi, Yuki, Ohba, Shinsuke, Chung, Ung-il, Tanaka, Sakae, Saito, Taku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581901/
https://www.ncbi.nlm.nih.gov/pubmed/36261443
http://dx.doi.org/10.1038/s41467-022-33744-5

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