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Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany

The literature has shown an inverse volume-outcome relationship for transcatheter aortic valve implantation (TAVI). However, little is known about emergency admissions in Germany. Using German national electronic health records, we identified all isolated balloon-expandable and self-expanding transf...

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Autores principales: Oettinger, Vera, Heidenreich, Adrian, Kaier, Klaus, Zehender, Manfred, Bode, Christoph, Duerschmied, Daniel, von zur Mühlen, Constantin, Westermann, Dirk, Stachon, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581927/
https://www.ncbi.nlm.nih.gov/pubmed/36261572
http://dx.doi.org/10.1038/s41598-022-20336-y
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author Oettinger, Vera
Heidenreich, Adrian
Kaier, Klaus
Zehender, Manfred
Bode, Christoph
Duerschmied, Daniel
von zur Mühlen, Constantin
Westermann, Dirk
Stachon, Peter
author_facet Oettinger, Vera
Heidenreich, Adrian
Kaier, Klaus
Zehender, Manfred
Bode, Christoph
Duerschmied, Daniel
von zur Mühlen, Constantin
Westermann, Dirk
Stachon, Peter
author_sort Oettinger, Vera
collection PubMed
description The literature has shown an inverse volume-outcome relationship for transcatheter aortic valve implantation (TAVI). However, little is known about emergency admissions in Germany. Using German national electronic health records, we identified all isolated balloon-expandable and self-expanding transfemoral TAVI in 2018. The focus was on those patients with emergency admission. 17,295 patients were treated with TAVI, including 1682 emergency cases. 49.2% of the emergency admissions were female, the mean age was 81.2 years and the logistic EuroSCORE was 23.3%. The percentage of emergency cases was higher in lower volume than in higher volume centers (p < 0.001): In detail, centers performing < 50 TAVI showed an emergency admission rate of ~ 15%, those with > 200 TAVI a rate of ~ 11%. After propensity score adjustment, analyzing the outcomes for an increase in volume per 10 emergency admissions, higher volume centers showed significantly better outcomes regarding in-hospital mortality (OR = 0.872, p = 0.043), major bleeding (OR = 0.772, p = 0.001), stroke (OR = 0.816, p = 0.044), mechanical ventilation > 48 h (OR = 0.749, p = 0.001), length of hospital stay (risk adjusted difference in days of hospitalization per 10 emergency admissions: − 1.01 days, p < 0.001), and reimbursement (risk adjusted difference in reimbursement per 10 emergency admissions: -€314.89, p < 0.001). Results were not significant for acute kidney injury (OR = 0.951, p = 0.104), postoperative delirium (OR = 0.975, p = 0.480), and permanent pacemaker implantation (OR = 1.010, p = 0.732). In conclusion, regarding transfemoral TAVI, the percentage of emergency cases was higher in lower volume centers in Germany. However, higher volume centers show significantly better outcomes for in-hospital mortality and complication rates as well as resource utilization parameters.
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spelling pubmed-95819272022-10-21 Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany Oettinger, Vera Heidenreich, Adrian Kaier, Klaus Zehender, Manfred Bode, Christoph Duerschmied, Daniel von zur Mühlen, Constantin Westermann, Dirk Stachon, Peter Sci Rep Article The literature has shown an inverse volume-outcome relationship for transcatheter aortic valve implantation (TAVI). However, little is known about emergency admissions in Germany. Using German national electronic health records, we identified all isolated balloon-expandable and self-expanding transfemoral TAVI in 2018. The focus was on those patients with emergency admission. 17,295 patients were treated with TAVI, including 1682 emergency cases. 49.2% of the emergency admissions were female, the mean age was 81.2 years and the logistic EuroSCORE was 23.3%. The percentage of emergency cases was higher in lower volume than in higher volume centers (p < 0.001): In detail, centers performing < 50 TAVI showed an emergency admission rate of ~ 15%, those with > 200 TAVI a rate of ~ 11%. After propensity score adjustment, analyzing the outcomes for an increase in volume per 10 emergency admissions, higher volume centers showed significantly better outcomes regarding in-hospital mortality (OR = 0.872, p = 0.043), major bleeding (OR = 0.772, p = 0.001), stroke (OR = 0.816, p = 0.044), mechanical ventilation > 48 h (OR = 0.749, p = 0.001), length of hospital stay (risk adjusted difference in days of hospitalization per 10 emergency admissions: − 1.01 days, p < 0.001), and reimbursement (risk adjusted difference in reimbursement per 10 emergency admissions: -€314.89, p < 0.001). Results were not significant for acute kidney injury (OR = 0.951, p = 0.104), postoperative delirium (OR = 0.975, p = 0.480), and permanent pacemaker implantation (OR = 1.010, p = 0.732). In conclusion, regarding transfemoral TAVI, the percentage of emergency cases was higher in lower volume centers in Germany. However, higher volume centers show significantly better outcomes for in-hospital mortality and complication rates as well as resource utilization parameters. Nature Publishing Group UK 2022-10-19 /pmc/articles/PMC9581927/ /pubmed/36261572 http://dx.doi.org/10.1038/s41598-022-20336-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Oettinger, Vera
Heidenreich, Adrian
Kaier, Klaus
Zehender, Manfred
Bode, Christoph
Duerschmied, Daniel
von zur Mühlen, Constantin
Westermann, Dirk
Stachon, Peter
Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany
title Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany
title_full Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany
title_fullStr Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany
title_full_unstemmed Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany
title_short Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany
title_sort hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in germany
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581927/
https://www.ncbi.nlm.nih.gov/pubmed/36261572
http://dx.doi.org/10.1038/s41598-022-20336-y
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