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Relationship between liver fat content and lifestyle factors in adults with metabolic syndrome
The aim of this study was to investigate the associations between liver fat content (LFC), sedentary behaviour (SB), physical activity (PA), fitness, diet, body composition, and cardiometabolic risk factors in adults with metabolic syndrome. A total of 44 sedentary adults (mean age 58 [SD 7] years;...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581946/ https://www.ncbi.nlm.nih.gov/pubmed/36261605 http://dx.doi.org/10.1038/s41598-022-22361-3 |
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author | Laine, Saara Sjöros, Tanja Garthwaite, Taru Saarenhovi, Maria Kallio, Petri Löyttyniemi, Eliisa Vähä-Ypyä, Henri Sievänen, Harri Vasankari, Tommi Laitinen, Kirsi Houttu, Noora Saukko, Ekaterina Knuuti, Juhani Saunavaara, Virva Heinonen, Ilkka H. A. |
author_facet | Laine, Saara Sjöros, Tanja Garthwaite, Taru Saarenhovi, Maria Kallio, Petri Löyttyniemi, Eliisa Vähä-Ypyä, Henri Sievänen, Harri Vasankari, Tommi Laitinen, Kirsi Houttu, Noora Saukko, Ekaterina Knuuti, Juhani Saunavaara, Virva Heinonen, Ilkka H. A. |
author_sort | Laine, Saara |
collection | PubMed |
description | The aim of this study was to investigate the associations between liver fat content (LFC), sedentary behaviour (SB), physical activity (PA), fitness, diet, body composition, and cardiometabolic risk factors in adults with metabolic syndrome. A total of 44 sedentary adults (mean age 58 [SD 7] years; 25 women) with overweight or obesity participated. LFC was assessed with magnetic resonance spectroscopy and imaging, SB and PA with hip-worn accelerometers (26 [SD 3] days), fitness by maximal bicycle ergometry, body composition by air displacement plethysmography and nutrient intake by 4-day food diaries. LFC was not independently associated with SB, PA or fitness. Adjusted for sex and age, LFC was associated with body fat%, body mass index, waist circumference, triglycerides, alanine aminotransferase, and with insulin resistance markers. There was and inverse association between LFC and daily protein intake, which persisted after further adjusment with body fat%. LFC is positively associated with body adiposity and cardiometabolic risk factors, and inversely with daily protein intake. SB, habitual PA or fitness are not independent modulators of LFC. However, as PA is an essential component of healthy lifestyle, it may contribute to liver health indirectly through its effects on body composition in adults with metabolic syndrome. |
format | Online Article Text |
id | pubmed-9581946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-95819462022-10-21 Relationship between liver fat content and lifestyle factors in adults with metabolic syndrome Laine, Saara Sjöros, Tanja Garthwaite, Taru Saarenhovi, Maria Kallio, Petri Löyttyniemi, Eliisa Vähä-Ypyä, Henri Sievänen, Harri Vasankari, Tommi Laitinen, Kirsi Houttu, Noora Saukko, Ekaterina Knuuti, Juhani Saunavaara, Virva Heinonen, Ilkka H. A. Sci Rep Article The aim of this study was to investigate the associations between liver fat content (LFC), sedentary behaviour (SB), physical activity (PA), fitness, diet, body composition, and cardiometabolic risk factors in adults with metabolic syndrome. A total of 44 sedentary adults (mean age 58 [SD 7] years; 25 women) with overweight or obesity participated. LFC was assessed with magnetic resonance spectroscopy and imaging, SB and PA with hip-worn accelerometers (26 [SD 3] days), fitness by maximal bicycle ergometry, body composition by air displacement plethysmography and nutrient intake by 4-day food diaries. LFC was not independently associated with SB, PA or fitness. Adjusted for sex and age, LFC was associated with body fat%, body mass index, waist circumference, triglycerides, alanine aminotransferase, and with insulin resistance markers. There was and inverse association between LFC and daily protein intake, which persisted after further adjusment with body fat%. LFC is positively associated with body adiposity and cardiometabolic risk factors, and inversely with daily protein intake. SB, habitual PA or fitness are not independent modulators of LFC. However, as PA is an essential component of healthy lifestyle, it may contribute to liver health indirectly through its effects on body composition in adults with metabolic syndrome. Nature Publishing Group UK 2022-10-19 /pmc/articles/PMC9581946/ /pubmed/36261605 http://dx.doi.org/10.1038/s41598-022-22361-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Laine, Saara Sjöros, Tanja Garthwaite, Taru Saarenhovi, Maria Kallio, Petri Löyttyniemi, Eliisa Vähä-Ypyä, Henri Sievänen, Harri Vasankari, Tommi Laitinen, Kirsi Houttu, Noora Saukko, Ekaterina Knuuti, Juhani Saunavaara, Virva Heinonen, Ilkka H. A. Relationship between liver fat content and lifestyle factors in adults with metabolic syndrome |
title | Relationship between liver fat content and lifestyle factors in adults with metabolic syndrome |
title_full | Relationship between liver fat content and lifestyle factors in adults with metabolic syndrome |
title_fullStr | Relationship between liver fat content and lifestyle factors in adults with metabolic syndrome |
title_full_unstemmed | Relationship between liver fat content and lifestyle factors in adults with metabolic syndrome |
title_short | Relationship between liver fat content and lifestyle factors in adults with metabolic syndrome |
title_sort | relationship between liver fat content and lifestyle factors in adults with metabolic syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581946/ https://www.ncbi.nlm.nih.gov/pubmed/36261605 http://dx.doi.org/10.1038/s41598-022-22361-3 |
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