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Reconstruction of time-shifted hemodynamic response
Regression of voxel time course onto expected response is a standard procedure in functional magnetic resonance imaging that relies on exact onset time and shape of superimposed hemodynamic response functions. Elegant capture of time deviation by time derivative regressors appears complicated by sha...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581965/ https://www.ncbi.nlm.nih.gov/pubmed/36261655 http://dx.doi.org/10.1038/s41598-022-17601-5 |
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author | Herrnberger, Bärbel |
author_facet | Herrnberger, Bärbel |
author_sort | Herrnberger, Bärbel |
collection | PubMed |
description | Regression of voxel time course onto expected response is a standard procedure in functional magnetic resonance imaging that relies on exact onset time and shape of superimposed hemodynamic response functions. Elegant capture of time deviation by time derivative regressors appears complicated by shape distortion and limited to ±1 s, and is usually not exploited for reconstructing the true time-shifted response function together with its magnitude. This analysis of the time-derivative approach provides closed-form functional relations between time shift and regression coefficients that allow for hemodynamic shifts of ±5 s and can explain shape distortion and reconstruction behavior. Reliable absolute latencies were no smaller than 0.6 s in a best-case experiment. Confusions of latency are a previously undiscussed shortcoming where current limitation strategy may eliminate correct latencies and protect incorrect ones. |
format | Online Article Text |
id | pubmed-9581965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-95819652022-10-21 Reconstruction of time-shifted hemodynamic response Herrnberger, Bärbel Sci Rep Article Regression of voxel time course onto expected response is a standard procedure in functional magnetic resonance imaging that relies on exact onset time and shape of superimposed hemodynamic response functions. Elegant capture of time deviation by time derivative regressors appears complicated by shape distortion and limited to ±1 s, and is usually not exploited for reconstructing the true time-shifted response function together with its magnitude. This analysis of the time-derivative approach provides closed-form functional relations between time shift and regression coefficients that allow for hemodynamic shifts of ±5 s and can explain shape distortion and reconstruction behavior. Reliable absolute latencies were no smaller than 0.6 s in a best-case experiment. Confusions of latency are a previously undiscussed shortcoming where current limitation strategy may eliminate correct latencies and protect incorrect ones. Nature Publishing Group UK 2022-10-19 /pmc/articles/PMC9581965/ /pubmed/36261655 http://dx.doi.org/10.1038/s41598-022-17601-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Herrnberger, Bärbel Reconstruction of time-shifted hemodynamic response |
title | Reconstruction of time-shifted hemodynamic response |
title_full | Reconstruction of time-shifted hemodynamic response |
title_fullStr | Reconstruction of time-shifted hemodynamic response |
title_full_unstemmed | Reconstruction of time-shifted hemodynamic response |
title_short | Reconstruction of time-shifted hemodynamic response |
title_sort | reconstruction of time-shifted hemodynamic response |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581965/ https://www.ncbi.nlm.nih.gov/pubmed/36261655 http://dx.doi.org/10.1038/s41598-022-17601-5 |
work_keys_str_mv | AT herrnbergerbarbel reconstructionoftimeshiftedhemodynamicresponse |