Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications

Triplication of the SNCA gene, encoding the protein alpha-Synuclein (αSyn), is a rare cause of aggressive and early-onset parkinsonism. Herein, we generated iPSCs from two siblings with a recently described compact SNCA gene triplication and suffering from severe motor impairments, psychiatric sympt...

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Detalles Bibliográficos
Autores principales: Iannielli, Angelo, Luoni, Mirko, Giannelli, Serena Gea, Ferese, Rosangela, Ordazzo, Gabriele, Fossati, Matteo, Raimondi, Andrea, Opazo, Felipe, Corti, Olga, Prehn, Jochen H. M., Gambardella, Stefano, Melki, Ronald, Broccoli, Vania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581971/
https://www.ncbi.nlm.nih.gov/pubmed/36261424
http://dx.doi.org/10.1038/s41419-022-05330-6

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