Spatial transcriptome profiling of normal human liver

The comprehensive study of the spatial-cellular anatomy of the human liver is critical to addressing the cellular origins of liver disease. Here we conducted spatial transcriptomics on normal human liver tissue sections, providing detailed information of liver zonation at the transcriptional level....

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Autores principales: Yu, Shizhe, Wang, Haoren, Yang, Lingpeng, Yan, Yingxue, Cai, Qiang, Ma, Duo, Jiang, Long, Gao, Zehai, Yu, Zhiyong, Xia, Zongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Data Descriptor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581974/
https://www.ncbi.nlm.nih.gov/pubmed/36261431
http://dx.doi.org/10.1038/s41597-022-01676-w
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author Yu, Shizhe
Wang, Haoren
Yang, Lingpeng
Yan, Yingxue
Cai, Qiang
Ma, Duo
Jiang, Long
Gao, Zehai
Yu, Zhiyong
Xia, Zongping
author_facet Yu, Shizhe
Wang, Haoren
Yang, Lingpeng
Yan, Yingxue
Cai, Qiang
Ma, Duo
Jiang, Long
Gao, Zehai
Yu, Zhiyong
Xia, Zongping
author_sort Yu, Shizhe
collection PubMed
description The comprehensive study of the spatial-cellular anatomy of the human liver is critical to addressing the cellular origins of liver disease. Here we conducted spatial transcriptomics on normal human liver tissue sections, providing detailed information of liver zonation at the transcriptional level. We present 6581 high-quality spots from normal livers of two human donors. In this dataset, cells were mainly hepatocytes, and we classified them into four sub-groups. Collectively, these data provide a reliable reference for studies on spatial heterogeneity of liver lobules.
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spelling pubmed-95819742022-10-21 Spatial transcriptome profiling of normal human liver Yu, Shizhe Wang, Haoren Yang, Lingpeng Yan, Yingxue Cai, Qiang Ma, Duo Jiang, Long Gao, Zehai Yu, Zhiyong Xia, Zongping Sci Data Data Descriptor The comprehensive study of the spatial-cellular anatomy of the human liver is critical to addressing the cellular origins of liver disease. Here we conducted spatial transcriptomics on normal human liver tissue sections, providing detailed information of liver zonation at the transcriptional level. We present 6581 high-quality spots from normal livers of two human donors. In this dataset, cells were mainly hepatocytes, and we classified them into four sub-groups. Collectively, these data provide a reliable reference for studies on spatial heterogeneity of liver lobules. Nature Publishing Group UK 2022-10-19 /pmc/articles/PMC9581974/ /pubmed/36261431 http://dx.doi.org/10.1038/s41597-022-01676-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Data Descriptor
Yu, Shizhe
Wang, Haoren
Yang, Lingpeng
Yan, Yingxue
Cai, Qiang
Ma, Duo
Jiang, Long
Gao, Zehai
Yu, Zhiyong
Xia, Zongping
Spatial transcriptome profiling of normal human liver
title Spatial transcriptome profiling of normal human liver
title_full Spatial transcriptome profiling of normal human liver
title_fullStr Spatial transcriptome profiling of normal human liver
title_full_unstemmed Spatial transcriptome profiling of normal human liver
title_short Spatial transcriptome profiling of normal human liver
title_sort spatial transcriptome profiling of normal human liver
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581974/
https://www.ncbi.nlm.nih.gov/pubmed/36261431
http://dx.doi.org/10.1038/s41597-022-01676-w
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