P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells

Glioma stem cells (GSC) exhibit plasticity in response to environmental and therapeutic stress leading to tumor recurrence, but the underlying mechanisms remain largely unknown. Here, we employ single-cell and whole transcriptomic analyses to uncover that radiation induces a dynamic shift in functio...

Descripción completa

Detalles Bibliográficos
Autores principales: Muthukrishnan, Sree Deepthi, Kawaguchi, Riki, Nair, Pooja, Prasad, Rachna, Qin, Yue, Johnson, Maverick, Wang, Qing, VanderVeer-Harris, Nathan, Pham, Amy, Alvarado, Alvaro G., Condro, Michael C., Gao, Fuying, Gau, Raymond, Castro, Maria G., Lowenstein, Pedro R., Deb, Arjun, Hinman, Jason D., Pajonk, Frank, Burns, Terry C., Goldman, Steven A., Geschwind, Daniel H., Kornblum, Harley I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582000/
https://www.ncbi.nlm.nih.gov/pubmed/36261421
http://dx.doi.org/10.1038/s41467-022-33943-0

Ejemplares similares

Ejemplares similares