Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reacti...

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Detalles Bibliográficos
Autores principales: Paprckova, Darina, Niederlova, Veronika, Moudra, Alena, Drobek, Ales, Pribikova, Michaela, Janusova, Sarka, Schober, Kilian, Neuwirth, Ales, Michalik, Juraj, Huranova, Martina, Horkova, Veronika, Cesnekova, Michaela, Simova, Michaela, Prochazka, Jan, Balounova, Jana, Busch, Dirk H., Sedlacek, Radislav, Schwarzer, Martin, Stepanek, Ondrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582129/
https://www.ncbi.nlm.nih.gov/pubmed/36275704
http://dx.doi.org/10.3389/fimmu.2022.1009198

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