Cholesterol: Enhancing FGF2 translocation in unconventional secretion

Fibroblast growth factor (FGF2) is a potent mitogen that is secreted through an unconventional secretory pathway by crossing the plasma membrane directly. In this current issue, Lolicato et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202106123) find that the secretion process is promoted by...

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Detalles Bibliográficos
Autores principales: Wang, Haodong, Zhang, Min, Ge, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582227/
https://www.ncbi.nlm.nih.gov/pubmed/36255389
http://dx.doi.org/10.1083/jcb.202210007
Descripción
Sumario:Fibroblast growth factor (FGF2) is a potent mitogen that is secreted through an unconventional secretory pathway by crossing the plasma membrane directly. In this current issue, Lolicato et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202106123) find that the secretion process is promoted by cholesterol, which enhances PI(4,5)P(2) accessibility to FGF2 binding and alters membrane property to increase FGF2 translocation.

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