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Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice

Increasing evidence has demonstrated that emotional states and intestinal conditions are inter-connected in so-called “brain–gut interactions.” Indeed, many psychiatric disorders are accompanied by gastrointestinal symptoms, such as the irritable bowel syndrome (IBS). However, the functional connect...

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Autores principales: Yoshioka, Toshinori, Ohashi, Misaki, Matsumoto, Kenjiro, Omata, Tomoki, Hamano, Takumi, Yamazaki, Mayuna, Kimiki, Sayaka, Okano, Kotaro, Kobayashi, Riho, Yamada, Daisuke, Hada, Noriyasu, Kato, Shinichi, Saitoh, Akiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582264/
https://www.ncbi.nlm.nih.gov/pubmed/36277999
http://dx.doi.org/10.3389/fnins.2022.993132
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author Yoshioka, Toshinori
Ohashi, Misaki
Matsumoto, Kenjiro
Omata, Tomoki
Hamano, Takumi
Yamazaki, Mayuna
Kimiki, Sayaka
Okano, Kotaro
Kobayashi, Riho
Yamada, Daisuke
Hada, Noriyasu
Kato, Shinichi
Saitoh, Akiyoshi
author_facet Yoshioka, Toshinori
Ohashi, Misaki
Matsumoto, Kenjiro
Omata, Tomoki
Hamano, Takumi
Yamazaki, Mayuna
Kimiki, Sayaka
Okano, Kotaro
Kobayashi, Riho
Yamada, Daisuke
Hada, Noriyasu
Kato, Shinichi
Saitoh, Akiyoshi
author_sort Yoshioka, Toshinori
collection PubMed
description Increasing evidence has demonstrated that emotional states and intestinal conditions are inter-connected in so-called “brain–gut interactions.” Indeed, many psychiatric disorders are accompanied by gastrointestinal symptoms, such as the irritable bowel syndrome (IBS). However, the functional connection remains elusive, partly because there are few useful experimental animal models. Here, we focused on a highly validated animal model of stress-induced psychiatric disorders, such as depression, known as the chronic vicarious social defeat stress (cVSDS) model mice, which we prepared using exposure to repeated psychological stress, thereafter examining their intestinal conditions. In the charcoal meal test and the capsaicin-induced hyperalgesia test, cVSDS model mice showed a significantly higher intestinal transit ratio and increased visceral pain-related behaviors, respectively. These changes persisted over one month after the stress session. On the other hand, the pathological evaluations of the histological and inflammatory scores of naive and cVSDS model mice did not differ. Furthermore, keishikashakuyakuto—a kampo medicine clinically used for the treatment of IBS—normalized the intestinal motility change in cVSDS model mice. Our results indicate that cVSDS model mice present IBS-like symptoms such as chronic intestinal peristaltic changes and abdominal hyperalgesia without organic lesion. We therefore propose the cVSDS paradigm as a novel animal model of IBS with wide validity, elucidating the correlation between depressive states and intestinal abnormalities.
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spelling pubmed-95822642022-10-21 Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice Yoshioka, Toshinori Ohashi, Misaki Matsumoto, Kenjiro Omata, Tomoki Hamano, Takumi Yamazaki, Mayuna Kimiki, Sayaka Okano, Kotaro Kobayashi, Riho Yamada, Daisuke Hada, Noriyasu Kato, Shinichi Saitoh, Akiyoshi Front Neurosci Neuroscience Increasing evidence has demonstrated that emotional states and intestinal conditions are inter-connected in so-called “brain–gut interactions.” Indeed, many psychiatric disorders are accompanied by gastrointestinal symptoms, such as the irritable bowel syndrome (IBS). However, the functional connection remains elusive, partly because there are few useful experimental animal models. Here, we focused on a highly validated animal model of stress-induced psychiatric disorders, such as depression, known as the chronic vicarious social defeat stress (cVSDS) model mice, which we prepared using exposure to repeated psychological stress, thereafter examining their intestinal conditions. In the charcoal meal test and the capsaicin-induced hyperalgesia test, cVSDS model mice showed a significantly higher intestinal transit ratio and increased visceral pain-related behaviors, respectively. These changes persisted over one month after the stress session. On the other hand, the pathological evaluations of the histological and inflammatory scores of naive and cVSDS model mice did not differ. Furthermore, keishikashakuyakuto—a kampo medicine clinically used for the treatment of IBS—normalized the intestinal motility change in cVSDS model mice. Our results indicate that cVSDS model mice present IBS-like symptoms such as chronic intestinal peristaltic changes and abdominal hyperalgesia without organic lesion. We therefore propose the cVSDS paradigm as a novel animal model of IBS with wide validity, elucidating the correlation between depressive states and intestinal abnormalities. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9582264/ /pubmed/36277999 http://dx.doi.org/10.3389/fnins.2022.993132 Text en Copyright © 2022 Yoshioka, Ohashi, Matsumoto, Omata, Hamano, Yamazaki, Kimiki, Okano, Kobayashi, Yamada, Hada, Kato and Saitoh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yoshioka, Toshinori
Ohashi, Misaki
Matsumoto, Kenjiro
Omata, Tomoki
Hamano, Takumi
Yamazaki, Mayuna
Kimiki, Sayaka
Okano, Kotaro
Kobayashi, Riho
Yamada, Daisuke
Hada, Noriyasu
Kato, Shinichi
Saitoh, Akiyoshi
Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice
title Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice
title_full Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice
title_fullStr Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice
title_full_unstemmed Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice
title_short Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice
title_sort repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582264/
https://www.ncbi.nlm.nih.gov/pubmed/36277999
http://dx.doi.org/10.3389/fnins.2022.993132
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