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Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice
Increasing evidence has demonstrated that emotional states and intestinal conditions are inter-connected in so-called “brain–gut interactions.” Indeed, many psychiatric disorders are accompanied by gastrointestinal symptoms, such as the irritable bowel syndrome (IBS). However, the functional connect...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582264/ https://www.ncbi.nlm.nih.gov/pubmed/36277999 http://dx.doi.org/10.3389/fnins.2022.993132 |
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author | Yoshioka, Toshinori Ohashi, Misaki Matsumoto, Kenjiro Omata, Tomoki Hamano, Takumi Yamazaki, Mayuna Kimiki, Sayaka Okano, Kotaro Kobayashi, Riho Yamada, Daisuke Hada, Noriyasu Kato, Shinichi Saitoh, Akiyoshi |
author_facet | Yoshioka, Toshinori Ohashi, Misaki Matsumoto, Kenjiro Omata, Tomoki Hamano, Takumi Yamazaki, Mayuna Kimiki, Sayaka Okano, Kotaro Kobayashi, Riho Yamada, Daisuke Hada, Noriyasu Kato, Shinichi Saitoh, Akiyoshi |
author_sort | Yoshioka, Toshinori |
collection | PubMed |
description | Increasing evidence has demonstrated that emotional states and intestinal conditions are inter-connected in so-called “brain–gut interactions.” Indeed, many psychiatric disorders are accompanied by gastrointestinal symptoms, such as the irritable bowel syndrome (IBS). However, the functional connection remains elusive, partly because there are few useful experimental animal models. Here, we focused on a highly validated animal model of stress-induced psychiatric disorders, such as depression, known as the chronic vicarious social defeat stress (cVSDS) model mice, which we prepared using exposure to repeated psychological stress, thereafter examining their intestinal conditions. In the charcoal meal test and the capsaicin-induced hyperalgesia test, cVSDS model mice showed a significantly higher intestinal transit ratio and increased visceral pain-related behaviors, respectively. These changes persisted over one month after the stress session. On the other hand, the pathological evaluations of the histological and inflammatory scores of naive and cVSDS model mice did not differ. Furthermore, keishikashakuyakuto—a kampo medicine clinically used for the treatment of IBS—normalized the intestinal motility change in cVSDS model mice. Our results indicate that cVSDS model mice present IBS-like symptoms such as chronic intestinal peristaltic changes and abdominal hyperalgesia without organic lesion. We therefore propose the cVSDS paradigm as a novel animal model of IBS with wide validity, elucidating the correlation between depressive states and intestinal abnormalities. |
format | Online Article Text |
id | pubmed-9582264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95822642022-10-21 Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice Yoshioka, Toshinori Ohashi, Misaki Matsumoto, Kenjiro Omata, Tomoki Hamano, Takumi Yamazaki, Mayuna Kimiki, Sayaka Okano, Kotaro Kobayashi, Riho Yamada, Daisuke Hada, Noriyasu Kato, Shinichi Saitoh, Akiyoshi Front Neurosci Neuroscience Increasing evidence has demonstrated that emotional states and intestinal conditions are inter-connected in so-called “brain–gut interactions.” Indeed, many psychiatric disorders are accompanied by gastrointestinal symptoms, such as the irritable bowel syndrome (IBS). However, the functional connection remains elusive, partly because there are few useful experimental animal models. Here, we focused on a highly validated animal model of stress-induced psychiatric disorders, such as depression, known as the chronic vicarious social defeat stress (cVSDS) model mice, which we prepared using exposure to repeated psychological stress, thereafter examining their intestinal conditions. In the charcoal meal test and the capsaicin-induced hyperalgesia test, cVSDS model mice showed a significantly higher intestinal transit ratio and increased visceral pain-related behaviors, respectively. These changes persisted over one month after the stress session. On the other hand, the pathological evaluations of the histological and inflammatory scores of naive and cVSDS model mice did not differ. Furthermore, keishikashakuyakuto—a kampo medicine clinically used for the treatment of IBS—normalized the intestinal motility change in cVSDS model mice. Our results indicate that cVSDS model mice present IBS-like symptoms such as chronic intestinal peristaltic changes and abdominal hyperalgesia without organic lesion. We therefore propose the cVSDS paradigm as a novel animal model of IBS with wide validity, elucidating the correlation between depressive states and intestinal abnormalities. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9582264/ /pubmed/36277999 http://dx.doi.org/10.3389/fnins.2022.993132 Text en Copyright © 2022 Yoshioka, Ohashi, Matsumoto, Omata, Hamano, Yamazaki, Kimiki, Okano, Kobayashi, Yamada, Hada, Kato and Saitoh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Yoshioka, Toshinori Ohashi, Misaki Matsumoto, Kenjiro Omata, Tomoki Hamano, Takumi Yamazaki, Mayuna Kimiki, Sayaka Okano, Kotaro Kobayashi, Riho Yamada, Daisuke Hada, Noriyasu Kato, Shinichi Saitoh, Akiyoshi Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice |
title | Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice |
title_full | Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice |
title_fullStr | Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice |
title_full_unstemmed | Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice |
title_short | Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice |
title_sort | repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582264/ https://www.ncbi.nlm.nih.gov/pubmed/36277999 http://dx.doi.org/10.3389/fnins.2022.993132 |
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