Cargando…

Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis

Non-alcoholic fatty liver disease (NAFLD) is a common cause of liver disease worldwide, and is characterized by the accumulation of fat in the liver. Non-alcoholic steatohepatitis (NASH), an advanced form of NAFLD, is a leading cause of liver transplantation. Fibrosis is the histologic feature most...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Amy, Cable, Carson, Sharma, Sachin, Shihan, Mahbubul H., Mattis, Aras N., Mileva, Izolda, Hannun, Yusuf A., Duwaerts, Caroline C., Chen, Jennifer Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582277/ https://www.ncbi.nlm.nih.gov/pubmed/36275798 http://dx.doi.org/10.3389/fmed.2022.881848

Ejemplares similares

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response
por: Xu, Ruijuan, et al.
Publicado: (2016)

CD18 deficiency improves liver injury in the MCD model of steatohepatitis
por: Pierce, Andrew A., et al.
Publicado: (2017)

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase
por: Bai, Aiping, et al.
Publicado: (2017)

AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells
por: Coant, Nicolas, et al.
Publicado: (2018)

Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress
por: Wang, Kai, et al.
Publicado: (2020)

Artemether Ameliorates Non-Alcoholic Steatohepatitis by Repressing Lipogenesis, Inflammation, and Fibrosis in Mice
por: Xu, Jia, et al.
Publicado: (2022)

Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn(2+)-dependent amidases
por: Yi, Jae Kyo, et al.
Publicado: (2022)

Correction: Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress
por: Wang, Kai, et al.
Publicado: (2020)

Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2
por: Xu, Ruijuan, et al.
Publicado: (2017)

Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis
por: Gardner, Aaron I., et al.
Publicado: (2020)

Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury
por: Sears, Sophia M., et al.
Publicado: (2022)

Colesevelam ameliorates non-alcoholic steatohepatitis and obesity in mice
por: Hartmann, Phillipp, et al.
Publicado: (2022)

Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections
por: Becker, Katrin Anne, et al.
Publicado: (2021)

Simvastatin Ameliorates Liver Fibrosis via Mediating Nitric Oxide Synthase in Rats with Non-Alcoholic Steatohepatitis-Related Liver Fibrosis
por: Wang, Wei, et al.
Publicado: (2013)

Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction
por: Katz, Michael G., et al.
Publicado: (2023)

Berberine ameliorates non-alcoholic steatohepatitis in ApoE(−/−) mice
por: Yang, Jin, et al.
Publicado: (2017)

The cellular pathways of liver fibrosis in non-alcoholic steatohepatitis
por: Méndez-Sánchez, Nahum, et al.
Publicado: (2020)

Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis
por: Lee, Kuei-Chuan, et al.
Publicado: (2023)

Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis
por: Kessoku, Takaomi, et al.
Publicado: (2016)

1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase
por: Truman, Jean-Philip, et al.
Publicado: (2021)

Tanshinone IIA regulates the TGF-β1/Smad signaling pathway to ameliorate non-alcoholic steatohepatitis-related fibrosis
por: Xu, Lianjie, et al.
Publicado: (2022)

Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells
por: Lin, Chih-Li, et al.
Publicado: (2017)

P2X7 Receptor in Alcoholic Steatohepatitis and Alcoholic Liver Fibrosis
por: Xia, Guo-Qing, et al.
Publicado: (2022)

β-glycosphingolipids ameliorated non-alcoholic steatohepatitis in the Psammomys obesus model
por: Zigmond, Ehud, et al.
Publicado: (2014)

Chymase as a Possible Therapeutic Target for Amelioration of Non-Alcoholic Steatohepatitis
por: Takai, Shinji, et al.
Publicado: (2020)

GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress
por: Kim, Hyeon Ju, et al.
Publicado: (2020)

Economic burden of non-alcoholic steatohepatitis with significant fibrosis in Thailand
por: Phisalprapa, Pochamana, et al.
Publicado: (2021)

Metabolomic Predictors of Non-alcoholic Steatohepatitis and Advanced Fibrosis in Children
por: Kordy, Kattayoun, et al.
Publicado: (2021)

CDase is a pan-ceramidase in Drosophila
por: Yuan, Changqing, et al.
Publicado: (2011)

Structural basis for the activation of acid ceramidase
por: Gebai, Ahmad, et al.
Publicado: (2018)

Adiponectin serenades ceramidase to improve metabolism
por: Reibe-Pal, Saskia, et al.
Publicado: (2017)

Presence of Ceramidase Activity in Electronegative LDL
por: Puig, Núria, et al.
Publicado: (2022)

Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain
por: Wang, Kai, et al.
Publicado: (2015)

Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis
por: Gardner, Aaron Ions, et al.
Publicado: (2021)

Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain
por: Wang, Kai, et al.
Publicado: (2018)

Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system
por: Wang, K, et al.
Publicado: (2016)

An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis
por: Matsumoto, Masahiko, et al.
Publicado: (2013)

Non-Alcoholic Steatohepatitis Decreases Microsomal Liver Function in the Absence of Fibrosis
por: Verlinden, Wim, et al.
Publicado: (2020)

Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis
por: Angelini, Giulia, et al.
Publicado: (2023)

Acid ceramidase confers radioresistance to glioblastoma cells
por: Doan, Ninh B., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dtihim1rkhdlalkei9s2451pgj