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Integrative pan-cancer landscape of MMS22L and its potential role in hepatocellular carcinoma

Methyl methanesulfonate-sensitivity protein 22-like (MMS22L) is crucial in protecting genome integrity during DNA replication by preventing DNA damage and maintaining efficient homologous recombination. However, the role of MMS22L in human cancers remains unclear. Here, we reported the landscape of...

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Autores principales: Guo, Zhiting, Liu, Fahui, Gong, Qiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582350/
https://www.ncbi.nlm.nih.gov/pubmed/36276962
http://dx.doi.org/10.3389/fgene.2022.1025970
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author Guo, Zhiting
Liu, Fahui
Gong, Qiming
author_facet Guo, Zhiting
Liu, Fahui
Gong, Qiming
author_sort Guo, Zhiting
collection PubMed
description Methyl methanesulfonate-sensitivity protein 22-like (MMS22L) is crucial in protecting genome integrity during DNA replication by preventing DNA damage and maintaining efficient homologous recombination. However, the role of MMS22L in human cancers remains unclear. Here, we reported the landscape of MMS22L using multi-omics data and identified the relationship between the MMS22L status and pan-cancer prognosis. In addition, the correlation of MMS22L mRNA expression levels with tumor mutational burden, microsatellite instability, homologous recombination deficiency, and loss of heterozygosity in pan-cancer was also described in this study. Furthermore, this study was the first to characterize the relationship between mRNA expression of MMS22L and immune cell infiltration in the tumor microenvironment in human cancer. Concurrently, this study explored the crucial role of MMS22L in different immunotherapy cohorts through current immunotherapy experiments. Eventually, we investigated the role of MMS22L in hepatocellular carcinoma (HCC). The results demonstrated that MMS22L is widely expressed in multiple HCC cell lines, and our results emphasized that MMS22L was involved in HCC progression and affects the prognosis of patients with HCC through multiple independent validation cohorts. Collectively, our findings reveal the essential role of MMS22L as a tumor-regulating gene in human cancers while further emphasizing its feasibility as a novel molecular marker in HCC. These findings provide an essential reference for the study of MMS22L in tumors.
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spelling pubmed-95823502022-10-21 Integrative pan-cancer landscape of MMS22L and its potential role in hepatocellular carcinoma Guo, Zhiting Liu, Fahui Gong, Qiming Front Genet Genetics Methyl methanesulfonate-sensitivity protein 22-like (MMS22L) is crucial in protecting genome integrity during DNA replication by preventing DNA damage and maintaining efficient homologous recombination. However, the role of MMS22L in human cancers remains unclear. Here, we reported the landscape of MMS22L using multi-omics data and identified the relationship between the MMS22L status and pan-cancer prognosis. In addition, the correlation of MMS22L mRNA expression levels with tumor mutational burden, microsatellite instability, homologous recombination deficiency, and loss of heterozygosity in pan-cancer was also described in this study. Furthermore, this study was the first to characterize the relationship between mRNA expression of MMS22L and immune cell infiltration in the tumor microenvironment in human cancer. Concurrently, this study explored the crucial role of MMS22L in different immunotherapy cohorts through current immunotherapy experiments. Eventually, we investigated the role of MMS22L in hepatocellular carcinoma (HCC). The results demonstrated that MMS22L is widely expressed in multiple HCC cell lines, and our results emphasized that MMS22L was involved in HCC progression and affects the prognosis of patients with HCC through multiple independent validation cohorts. Collectively, our findings reveal the essential role of MMS22L as a tumor-regulating gene in human cancers while further emphasizing its feasibility as a novel molecular marker in HCC. These findings provide an essential reference for the study of MMS22L in tumors. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9582350/ /pubmed/36276962 http://dx.doi.org/10.3389/fgene.2022.1025970 Text en Copyright © 2022 Guo, Liu and Gong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Guo, Zhiting
Liu, Fahui
Gong, Qiming
Integrative pan-cancer landscape of MMS22L and its potential role in hepatocellular carcinoma
title Integrative pan-cancer landscape of MMS22L and its potential role in hepatocellular carcinoma
title_full Integrative pan-cancer landscape of MMS22L and its potential role in hepatocellular carcinoma
title_fullStr Integrative pan-cancer landscape of MMS22L and its potential role in hepatocellular carcinoma
title_full_unstemmed Integrative pan-cancer landscape of MMS22L and its potential role in hepatocellular carcinoma
title_short Integrative pan-cancer landscape of MMS22L and its potential role in hepatocellular carcinoma
title_sort integrative pan-cancer landscape of mms22l and its potential role in hepatocellular carcinoma
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582350/
https://www.ncbi.nlm.nih.gov/pubmed/36276962
http://dx.doi.org/10.3389/fgene.2022.1025970
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