Disulfiram alleviates acute lung injury and related intestinal mucosal barrier impairment by targeting GSDMD-dependent pyroptosis

BACKGROUND: Pyroptosis was implicated in acute lung injury (ALI). Disulfiram is reported as an effective pyroptosis inhibitor by inhibiting gasdermin D(GSDMD). However, the function of pyroptosis executor GSDMD and treatment of disulfiramon on ALI, especially whether it was involved in ALI-associate...

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Detalles Bibliográficos
Autores principales: Zhao, Jiping, Wang, Hong, zhang, Jintao, Ou, Fuwei, Wang, Junfei, Liu, Tian, Wu, Jinxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582395/
https://www.ncbi.nlm.nih.gov/pubmed/36266722
http://dx.doi.org/10.1186/s12950-022-00313-y

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