Microglial autophagy in cerebrovascular diseases

Microglia are considered core regulators for monitoring homeostasis in the brain and primary responders to central nervous system (CNS) injuries. Autophagy affects the innate immune functions of microglia. Recently some evidence suggests that microglial autophagy is closely associated with brain fun...

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Autores principales: Chen, Man, Zhang, Hang, Chu, Yun-Hui, Tang, Yue, Pang, Xiao-Wei, Qin, Chuan, Tian, Dai-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582432/
https://www.ncbi.nlm.nih.gov/pubmed/36275005
http://dx.doi.org/10.3389/fnagi.2022.1023679
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author Chen, Man
Zhang, Hang
Chu, Yun-Hui
Tang, Yue
Pang, Xiao-Wei
Qin, Chuan
Tian, Dai-Shi
author_facet Chen, Man
Zhang, Hang
Chu, Yun-Hui
Tang, Yue
Pang, Xiao-Wei
Qin, Chuan
Tian, Dai-Shi
author_sort Chen, Man
collection PubMed
description Microglia are considered core regulators for monitoring homeostasis in the brain and primary responders to central nervous system (CNS) injuries. Autophagy affects the innate immune functions of microglia. Recently some evidence suggests that microglial autophagy is closely associated with brain function in both ischemic stroke and hemorrhagic stroke. Herein, we will discuss the interaction between autophagy and other biological processes in microglia under physiological and pathological conditions and highlight the interaction between microglial metabolism and autophagy. In the end, we focus on the effect of microglial autophagy in cerebrovascular diseases.
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spelling pubmed-95824322022-10-21 Microglial autophagy in cerebrovascular diseases Chen, Man Zhang, Hang Chu, Yun-Hui Tang, Yue Pang, Xiao-Wei Qin, Chuan Tian, Dai-Shi Front Aging Neurosci Neuroscience Microglia are considered core regulators for monitoring homeostasis in the brain and primary responders to central nervous system (CNS) injuries. Autophagy affects the innate immune functions of microglia. Recently some evidence suggests that microglial autophagy is closely associated with brain function in both ischemic stroke and hemorrhagic stroke. Herein, we will discuss the interaction between autophagy and other biological processes in microglia under physiological and pathological conditions and highlight the interaction between microglial metabolism and autophagy. In the end, we focus on the effect of microglial autophagy in cerebrovascular diseases. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9582432/ /pubmed/36275005 http://dx.doi.org/10.3389/fnagi.2022.1023679 Text en Copyright © 2022 Chen, Zhang, Chu, Tang, Pang, Qin and Tian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Chen, Man
Zhang, Hang
Chu, Yun-Hui
Tang, Yue
Pang, Xiao-Wei
Qin, Chuan
Tian, Dai-Shi
Microglial autophagy in cerebrovascular diseases
title Microglial autophagy in cerebrovascular diseases
title_full Microglial autophagy in cerebrovascular diseases
title_fullStr Microglial autophagy in cerebrovascular diseases
title_full_unstemmed Microglial autophagy in cerebrovascular diseases
title_short Microglial autophagy in cerebrovascular diseases
title_sort microglial autophagy in cerebrovascular diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582432/
https://www.ncbi.nlm.nih.gov/pubmed/36275005
http://dx.doi.org/10.3389/fnagi.2022.1023679
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AT tangyue microglialautophagyincerebrovasculardiseases
AT pangxiaowei microglialautophagyincerebrovasculardiseases
AT qinchuan microglialautophagyincerebrovasculardiseases
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