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Role of Local Treatment for Oligometastasis: A Comparability-Based Meta-Analysis

PURPOSE: We intend to investigate the oncological efficacy and feasibility of local consolidative therapy (LCT) through a meta-analysis method. MATERIALS AND METHODS: Four databases including PubMed, MEDLINE, Embase, and Cochrane library were searched. Target studies are controlled trials comparing...

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Autores principales: Rim, Chai Hong, Cho, Won Kyung, Lee, Jong Hoon, Kim, Young Seok, Suh, Yang-Gun, Kim, Kyung Hwan, Chie, Eui Kyu, Ahn, Yong Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582460/
https://www.ncbi.nlm.nih.gov/pubmed/35989655
http://dx.doi.org/10.4143/crt.2022.329
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author Rim, Chai Hong
Cho, Won Kyung
Lee, Jong Hoon
Kim, Young Seok
Suh, Yang-Gun
Kim, Kyung Hwan
Chie, Eui Kyu
Ahn, Yong Chan
author_facet Rim, Chai Hong
Cho, Won Kyung
Lee, Jong Hoon
Kim, Young Seok
Suh, Yang-Gun
Kim, Kyung Hwan
Chie, Eui Kyu
Ahn, Yong Chan
author_sort Rim, Chai Hong
collection PubMed
description PURPOSE: We intend to investigate the oncological efficacy and feasibility of local consolidative therapy (LCT) through a meta-analysis method. MATERIALS AND METHODS: Four databases including PubMed, MEDLINE, Embase, and Cochrane library were searched. Target studies are controlled trials comparing outcomes of LCT versus a control group. Primary endpoints are overall survival (OS) and progression-free survival (PFS). RESULTS: A total of 54 studies involving 7,242 patients were included. Pooled analyses showed that the LCT arm could achieve improved OS with pooled odds ratio of 2.896 (95% confidence interval [CI], 2.377 to 3.528; p < 0.001). Regarding PFS, pooled analyses showed pooled odds ratio of 3.045 (95% CI, 2.356 to 3.937; p < 0.001) in favor of the LCT arm. In the subgroup analyses including the studies with reliable comparability (e.g. randomized studies or intentionally matched studies without significant favorable prognosticator in LCT arms), pooled odds ratio was 2.548 (95% CI, 1.808 to 3.591; p < 0.001) favoring the LCT arm regarding OS. Regarding PFS, pooled OR was 2.656 (95% CI, 1.713 to 4.120; p < 0.001) which also favored the LCT arm. Subgroup analyses limited to the randomized controlled trials (RCT) were also performed and pooled odds ratios on OS and PFS were 1.535 (95% CI, 1.082 to 2.177; p=0.016) and 1.668 (95% CI, 1.187 to 2.344; p=0.003). The rates of grade ≥ 3 complications related to LCT was mostly low (< 10%) and not significantly higher compared to the control arm. CONCLUSION: Pooled analyses results of all included studies, selected studies with reliable comparability, and RCT’s demonstrated the survival benefit of LCT. These consistent results suggest that LCT was beneficial to the patients with oligometastasis.
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spelling pubmed-95824602022-10-26 Role of Local Treatment for Oligometastasis: A Comparability-Based Meta-Analysis Rim, Chai Hong Cho, Won Kyung Lee, Jong Hoon Kim, Young Seok Suh, Yang-Gun Kim, Kyung Hwan Chie, Eui Kyu Ahn, Yong Chan Cancer Res Treat Original Article PURPOSE: We intend to investigate the oncological efficacy and feasibility of local consolidative therapy (LCT) through a meta-analysis method. MATERIALS AND METHODS: Four databases including PubMed, MEDLINE, Embase, and Cochrane library were searched. Target studies are controlled trials comparing outcomes of LCT versus a control group. Primary endpoints are overall survival (OS) and progression-free survival (PFS). RESULTS: A total of 54 studies involving 7,242 patients were included. Pooled analyses showed that the LCT arm could achieve improved OS with pooled odds ratio of 2.896 (95% confidence interval [CI], 2.377 to 3.528; p < 0.001). Regarding PFS, pooled analyses showed pooled odds ratio of 3.045 (95% CI, 2.356 to 3.937; p < 0.001) in favor of the LCT arm. In the subgroup analyses including the studies with reliable comparability (e.g. randomized studies or intentionally matched studies without significant favorable prognosticator in LCT arms), pooled odds ratio was 2.548 (95% CI, 1.808 to 3.591; p < 0.001) favoring the LCT arm regarding OS. Regarding PFS, pooled OR was 2.656 (95% CI, 1.713 to 4.120; p < 0.001) which also favored the LCT arm. Subgroup analyses limited to the randomized controlled trials (RCT) were also performed and pooled odds ratios on OS and PFS were 1.535 (95% CI, 1.082 to 2.177; p=0.016) and 1.668 (95% CI, 1.187 to 2.344; p=0.003). The rates of grade ≥ 3 complications related to LCT was mostly low (< 10%) and not significantly higher compared to the control arm. CONCLUSION: Pooled analyses results of all included studies, selected studies with reliable comparability, and RCT’s demonstrated the survival benefit of LCT. These consistent results suggest that LCT was beneficial to the patients with oligometastasis. Korean Cancer Association 2022-10 2022-08-16 /pmc/articles/PMC9582460/ /pubmed/35989655 http://dx.doi.org/10.4143/crt.2022.329 Text en Copyright © 2022 by the Korean Cancer Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Rim, Chai Hong
Cho, Won Kyung
Lee, Jong Hoon
Kim, Young Seok
Suh, Yang-Gun
Kim, Kyung Hwan
Chie, Eui Kyu
Ahn, Yong Chan
Role of Local Treatment for Oligometastasis: A Comparability-Based Meta-Analysis
title Role of Local Treatment for Oligometastasis: A Comparability-Based Meta-Analysis
title_full Role of Local Treatment for Oligometastasis: A Comparability-Based Meta-Analysis
title_fullStr Role of Local Treatment for Oligometastasis: A Comparability-Based Meta-Analysis
title_full_unstemmed Role of Local Treatment for Oligometastasis: A Comparability-Based Meta-Analysis
title_short Role of Local Treatment for Oligometastasis: A Comparability-Based Meta-Analysis
title_sort role of local treatment for oligometastasis: a comparability-based meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582460/
https://www.ncbi.nlm.nih.gov/pubmed/35989655
http://dx.doi.org/10.4143/crt.2022.329
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