Pirfenidone exacerbates Th2-driven vasculopathy in a mouse model of systemic sclerosis-associated interstitial lung disease

BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disease characterised by severe vasculopathy and fibrosis of various organs including the lung. Targeted treatment options for SSc-associated interstitial lung disease (SSc-ILD) are scarce. We assessed the effects of pirfenidone in a mouse model...

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Detalles Bibliográficos
Autores principales: Birnhuber, Anna, Jandl, Katharina, Biasin, Valentina, Fließer, Elisabeth, Valzano, Francesco, Marsh, Leigh M., Krolczik, Christina, Olschewski, Andrea, Wilhelm, Jochen, Toller, Wolfgang, Heinemann, Akos, Olschewski, Horst, Wygrecka, Malgorzata, Kwapiszewska, Grazyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582508/
https://www.ncbi.nlm.nih.gov/pubmed/35332068
http://dx.doi.org/10.1183/13993003.02347-2021

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