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Long non-coding RNAs: Potential therapeutic targets for epilepsy
Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide. Long non-coding RNAs (LncRNAs) are a class of RNAs longer than 200 nucleotides without the capacity of protein coding, but they participate...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582525/ https://www.ncbi.nlm.nih.gov/pubmed/36278003 http://dx.doi.org/10.3389/fnins.2022.986874 |
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author | Liu, Sen Fan, Min Ma, Meng-Die Ge, Jin-Fang Chen, Fei-Hu |
author_facet | Liu, Sen Fan, Min Ma, Meng-Die Ge, Jin-Fang Chen, Fei-Hu |
author_sort | Liu, Sen |
collection | PubMed |
description | Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide. Long non-coding RNAs (LncRNAs) are a class of RNAs longer than 200 nucleotides without the capacity of protein coding, but they participate in a wide variety of pathophysiological processes. Alternated abundance and diversity of LncRNAs have been found in epilepsy patients and animal or cell models, suggesting a potential role of LncRNAs in epileptogenesis. This review will introduce the structure and function of LncRNAs, summarize the role of LncRNAs in the pathogenesis of epilepsy, especially its linkage with neuroinflammation, apoptosis, and transmitter balance, which will throw light on the molecular mechanism of epileptogenesis, and accelerate the clinical implementation of LncRNAs as a potential therapeutic target for treatment of epilepsy. |
format | Online Article Text |
id | pubmed-9582525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95825252022-10-21 Long non-coding RNAs: Potential therapeutic targets for epilepsy Liu, Sen Fan, Min Ma, Meng-Die Ge, Jin-Fang Chen, Fei-Hu Front Neurosci Neuroscience Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide. Long non-coding RNAs (LncRNAs) are a class of RNAs longer than 200 nucleotides without the capacity of protein coding, but they participate in a wide variety of pathophysiological processes. Alternated abundance and diversity of LncRNAs have been found in epilepsy patients and animal or cell models, suggesting a potential role of LncRNAs in epileptogenesis. This review will introduce the structure and function of LncRNAs, summarize the role of LncRNAs in the pathogenesis of epilepsy, especially its linkage with neuroinflammation, apoptosis, and transmitter balance, which will throw light on the molecular mechanism of epileptogenesis, and accelerate the clinical implementation of LncRNAs as a potential therapeutic target for treatment of epilepsy. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9582525/ /pubmed/36278003 http://dx.doi.org/10.3389/fnins.2022.986874 Text en Copyright © 2022 Liu, Fan, Ma, Ge and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Liu, Sen Fan, Min Ma, Meng-Die Ge, Jin-Fang Chen, Fei-Hu Long non-coding RNAs: Potential therapeutic targets for epilepsy |
title | Long non-coding RNAs: Potential therapeutic targets for epilepsy |
title_full | Long non-coding RNAs: Potential therapeutic targets for epilepsy |
title_fullStr | Long non-coding RNAs: Potential therapeutic targets for epilepsy |
title_full_unstemmed | Long non-coding RNAs: Potential therapeutic targets for epilepsy |
title_short | Long non-coding RNAs: Potential therapeutic targets for epilepsy |
title_sort | long non-coding rnas: potential therapeutic targets for epilepsy |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582525/ https://www.ncbi.nlm.nih.gov/pubmed/36278003 http://dx.doi.org/10.3389/fnins.2022.986874 |
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