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Long non-coding RNAs: Potential therapeutic targets for epilepsy

Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide. Long non-coding RNAs (LncRNAs) are a class of RNAs longer than 200 nucleotides without the capacity of protein coding, but they participate...

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Autores principales: Liu, Sen, Fan, Min, Ma, Meng-Die, Ge, Jin-Fang, Chen, Fei-Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582525/
https://www.ncbi.nlm.nih.gov/pubmed/36278003
http://dx.doi.org/10.3389/fnins.2022.986874
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author Liu, Sen
Fan, Min
Ma, Meng-Die
Ge, Jin-Fang
Chen, Fei-Hu
author_facet Liu, Sen
Fan, Min
Ma, Meng-Die
Ge, Jin-Fang
Chen, Fei-Hu
author_sort Liu, Sen
collection PubMed
description Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide. Long non-coding RNAs (LncRNAs) are a class of RNAs longer than 200 nucleotides without the capacity of protein coding, but they participate in a wide variety of pathophysiological processes. Alternated abundance and diversity of LncRNAs have been found in epilepsy patients and animal or cell models, suggesting a potential role of LncRNAs in epileptogenesis. This review will introduce the structure and function of LncRNAs, summarize the role of LncRNAs in the pathogenesis of epilepsy, especially its linkage with neuroinflammation, apoptosis, and transmitter balance, which will throw light on the molecular mechanism of epileptogenesis, and accelerate the clinical implementation of LncRNAs as a potential therapeutic target for treatment of epilepsy.
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spelling pubmed-95825252022-10-21 Long non-coding RNAs: Potential therapeutic targets for epilepsy Liu, Sen Fan, Min Ma, Meng-Die Ge, Jin-Fang Chen, Fei-Hu Front Neurosci Neuroscience Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide. Long non-coding RNAs (LncRNAs) are a class of RNAs longer than 200 nucleotides without the capacity of protein coding, but they participate in a wide variety of pathophysiological processes. Alternated abundance and diversity of LncRNAs have been found in epilepsy patients and animal or cell models, suggesting a potential role of LncRNAs in epileptogenesis. This review will introduce the structure and function of LncRNAs, summarize the role of LncRNAs in the pathogenesis of epilepsy, especially its linkage with neuroinflammation, apoptosis, and transmitter balance, which will throw light on the molecular mechanism of epileptogenesis, and accelerate the clinical implementation of LncRNAs as a potential therapeutic target for treatment of epilepsy. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9582525/ /pubmed/36278003 http://dx.doi.org/10.3389/fnins.2022.986874 Text en Copyright © 2022 Liu, Fan, Ma, Ge and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Sen
Fan, Min
Ma, Meng-Die
Ge, Jin-Fang
Chen, Fei-Hu
Long non-coding RNAs: Potential therapeutic targets for epilepsy
title Long non-coding RNAs: Potential therapeutic targets for epilepsy
title_full Long non-coding RNAs: Potential therapeutic targets for epilepsy
title_fullStr Long non-coding RNAs: Potential therapeutic targets for epilepsy
title_full_unstemmed Long non-coding RNAs: Potential therapeutic targets for epilepsy
title_short Long non-coding RNAs: Potential therapeutic targets for epilepsy
title_sort long non-coding rnas: potential therapeutic targets for epilepsy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582525/
https://www.ncbi.nlm.nih.gov/pubmed/36278003
http://dx.doi.org/10.3389/fnins.2022.986874
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