CRISPR/Cas9 and AAV mediated insertion of β2 microglobulin-HLA-G fusion gene protects mesenchymal stromal cells from allogeneic rejection and potentiates the use for off-the-shelf cell therapy

INTRODUCTION: Mesenchymal stromal cells (MSCs) hold the potential for application as cellular therapy products; however, there are many problems that need to be addressed before the use in clinical settings, these include the heterogeneity of MSCs, scalability in MSC production, timing and technique...

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Detalles Bibliográficos
Autores principales: Meshitsuka, Sohsuke, Ninomiya, Ryo, Nagamura-Inoue, Tokiko, Okada, Takashi, Futami, Muneyoshi, Tojo, Arinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582586/
https://www.ncbi.nlm.nih.gov/pubmed/36313397
http://dx.doi.org/10.1016/j.reth.2022.09.009

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