Lysosome docking to WIPI1 rings and ER-connected phagophores occurs during DNAJB12- and GABARAP-dependent selective autophagy of misfolded P23H-rhodopsin

We report on how the endoplasmic reticulum (ER)-associated-autophagy pathway (ERAA) delivers P23H-rhodopsin (P23H-R) to the lysosome. P23H-R accumulates in an ERAD-resistant conformation that is stabilized in a detergent-soluble state by DNAJB12 and Hsp70. P23H-R, DNAJB12, and FIP200 colocalize in d...

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Detalles Bibliográficos
Autores principales: Kennedy, Andrew, Ren, Hong Yu, Madden, Victoria J., Cyr, Douglas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582645/
https://www.ncbi.nlm.nih.gov/pubmed/35704470
http://dx.doi.org/10.1091/mbc.E21-10-0505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582645/
https://www.ncbi.nlm.nih.gov/pubmed/35704470
http://dx.doi.org/10.1091/mbc.E21-10-0505

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