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How does plasticity of migration help tumor cells to avoid treatment: Cytoskeletal regulators and potential markers

Tumor shrinkage as a result of antitumor therapy is not the only and sufficient indicator of treatment success. Cancer progression leads to dissemination of tumor cells and formation of metastases - secondary tumor lesions in distant organs. Metastasis is associated with acquisition of mobile phenot...

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Autores principales: Alexandrova, Antonina, Lomakina, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582651/
https://www.ncbi.nlm.nih.gov/pubmed/36278174
http://dx.doi.org/10.3389/fphar.2022.962652
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author Alexandrova, Antonina
Lomakina, Maria
author_facet Alexandrova, Antonina
Lomakina, Maria
author_sort Alexandrova, Antonina
collection PubMed
description Tumor shrinkage as a result of antitumor therapy is not the only and sufficient indicator of treatment success. Cancer progression leads to dissemination of tumor cells and formation of metastases - secondary tumor lesions in distant organs. Metastasis is associated with acquisition of mobile phenotype by tumor cells as a result of epithelial-to-mesenchymal transition and further cell migration based on cytoskeleton reorganization. The main mechanisms of individual cell migration are either mesenchymal, which depends on the activity of small GTPase Rac, actin polymerization, formation of adhesions with extracellular matrix and activity of proteolytic enzymes or amoeboid, which is based on the increase in intracellular pressure caused by the enhancement of actin cortex contractility regulated by Rho-ROCK-MLCKII pathway, and does not depend on the formation of adhesive structures with the matrix, nor on the activity of proteases. The ability of tumor cells to switch from one motility mode to another depending on cell context and environmental conditions, termed migratory plasticity, contributes to the efficiency of dissemination and often allows the cells to avoid the applied treatment. The search for new therapeutic targets among cytoskeletal proteins offers an opportunity to directly influence cell migration. For successful treatment it is important to assess the likelihood of migratory plasticity in a particular tumor. Therefore, the search for specific markers that can indicate a high probability of migratory plasticity is very important.
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spelling pubmed-95826512022-10-21 How does plasticity of migration help tumor cells to avoid treatment: Cytoskeletal regulators and potential markers Alexandrova, Antonina Lomakina, Maria Front Pharmacol Pharmacology Tumor shrinkage as a result of antitumor therapy is not the only and sufficient indicator of treatment success. Cancer progression leads to dissemination of tumor cells and formation of metastases - secondary tumor lesions in distant organs. Metastasis is associated with acquisition of mobile phenotype by tumor cells as a result of epithelial-to-mesenchymal transition and further cell migration based on cytoskeleton reorganization. The main mechanisms of individual cell migration are either mesenchymal, which depends on the activity of small GTPase Rac, actin polymerization, formation of adhesions with extracellular matrix and activity of proteolytic enzymes or amoeboid, which is based on the increase in intracellular pressure caused by the enhancement of actin cortex contractility regulated by Rho-ROCK-MLCKII pathway, and does not depend on the formation of adhesive structures with the matrix, nor on the activity of proteases. The ability of tumor cells to switch from one motility mode to another depending on cell context and environmental conditions, termed migratory plasticity, contributes to the efficiency of dissemination and often allows the cells to avoid the applied treatment. The search for new therapeutic targets among cytoskeletal proteins offers an opportunity to directly influence cell migration. For successful treatment it is important to assess the likelihood of migratory plasticity in a particular tumor. Therefore, the search for specific markers that can indicate a high probability of migratory plasticity is very important. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9582651/ /pubmed/36278174 http://dx.doi.org/10.3389/fphar.2022.962652 Text en Copyright © 2022 Alexandrova and Lomakina. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Alexandrova, Antonina
Lomakina, Maria
How does plasticity of migration help tumor cells to avoid treatment: Cytoskeletal regulators and potential markers
title How does plasticity of migration help tumor cells to avoid treatment: Cytoskeletal regulators and potential markers
title_full How does plasticity of migration help tumor cells to avoid treatment: Cytoskeletal regulators and potential markers
title_fullStr How does plasticity of migration help tumor cells to avoid treatment: Cytoskeletal regulators and potential markers
title_full_unstemmed How does plasticity of migration help tumor cells to avoid treatment: Cytoskeletal regulators and potential markers
title_short How does plasticity of migration help tumor cells to avoid treatment: Cytoskeletal regulators and potential markers
title_sort how does plasticity of migration help tumor cells to avoid treatment: cytoskeletal regulators and potential markers
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582651/
https://www.ncbi.nlm.nih.gov/pubmed/36278174
http://dx.doi.org/10.3389/fphar.2022.962652
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