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Recent and current advances in PET/CT imaging in the field of predicting epidermal growth factor receptor mutations in non-small cell lung cancer

Tyrosine kinase inhibitors (TKIs) are a significant treatment strategy for the management of non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation status. Currently, EGFR mutation status is established based on tumor tissue acquired by biopsy or resection, so there...

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Autores principales: Hu, Na, Yan, Gang, Wu, Yuhui, Wang, Li, Wang, Yang, Xiang, Yining, Lei, Pinggui, Luo, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582655/
https://www.ncbi.nlm.nih.gov/pubmed/36276079
http://dx.doi.org/10.3389/fonc.2022.879341
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author Hu, Na
Yan, Gang
Wu, Yuhui
Wang, Li
Wang, Yang
Xiang, Yining
Lei, Pinggui
Luo, Peng
author_facet Hu, Na
Yan, Gang
Wu, Yuhui
Wang, Li
Wang, Yang
Xiang, Yining
Lei, Pinggui
Luo, Peng
author_sort Hu, Na
collection PubMed
description Tyrosine kinase inhibitors (TKIs) are a significant treatment strategy for the management of non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation status. Currently, EGFR mutation status is established based on tumor tissue acquired by biopsy or resection, so there is a compelling need to develop non-invasive, rapid, and accurate gene mutation detection methods. Non-invasive molecular imaging, such as positron emission tomography/computed tomography (PET/CT), has been widely applied to obtain the tumor molecular and genomic features for NSCLC treatment. Recent studies have shown that PET/CT can precisely quantify EGFR mutation status in NSCLC patients for precision therapy. This review article discusses PET/CT advances in predicting EGFR mutation status in NSCLC and their clinical usefulness.
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spelling pubmed-95826552022-10-21 Recent and current advances in PET/CT imaging in the field of predicting epidermal growth factor receptor mutations in non-small cell lung cancer Hu, Na Yan, Gang Wu, Yuhui Wang, Li Wang, Yang Xiang, Yining Lei, Pinggui Luo, Peng Front Oncol Oncology Tyrosine kinase inhibitors (TKIs) are a significant treatment strategy for the management of non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation status. Currently, EGFR mutation status is established based on tumor tissue acquired by biopsy or resection, so there is a compelling need to develop non-invasive, rapid, and accurate gene mutation detection methods. Non-invasive molecular imaging, such as positron emission tomography/computed tomography (PET/CT), has been widely applied to obtain the tumor molecular and genomic features for NSCLC treatment. Recent studies have shown that PET/CT can precisely quantify EGFR mutation status in NSCLC patients for precision therapy. This review article discusses PET/CT advances in predicting EGFR mutation status in NSCLC and their clinical usefulness. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9582655/ /pubmed/36276079 http://dx.doi.org/10.3389/fonc.2022.879341 Text en Copyright © 2022 Hu, Yan, Wu, Wang, Wang, Xiang, Lei and Luo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Hu, Na
Yan, Gang
Wu, Yuhui
Wang, Li
Wang, Yang
Xiang, Yining
Lei, Pinggui
Luo, Peng
Recent and current advances in PET/CT imaging in the field of predicting epidermal growth factor receptor mutations in non-small cell lung cancer
title Recent and current advances in PET/CT imaging in the field of predicting epidermal growth factor receptor mutations in non-small cell lung cancer
title_full Recent and current advances in PET/CT imaging in the field of predicting epidermal growth factor receptor mutations in non-small cell lung cancer
title_fullStr Recent and current advances in PET/CT imaging in the field of predicting epidermal growth factor receptor mutations in non-small cell lung cancer
title_full_unstemmed Recent and current advances in PET/CT imaging in the field of predicting epidermal growth factor receptor mutations in non-small cell lung cancer
title_short Recent and current advances in PET/CT imaging in the field of predicting epidermal growth factor receptor mutations in non-small cell lung cancer
title_sort recent and current advances in pet/ct imaging in the field of predicting epidermal growth factor receptor mutations in non-small cell lung cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582655/
https://www.ncbi.nlm.nih.gov/pubmed/36276079
http://dx.doi.org/10.3389/fonc.2022.879341
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