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Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications

Bone tissue engineering has been becoming a promising strategy for surgical bone repair, but the risk of infection during trauma repair remains a problematic health concern worldwide, especially for fracture and infection-caused bone defects. Conventional antibiotics fail to effectively prevent or t...

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Autores principales: Hao, Zhuowen, Chen, Renxin, Chai, Chen, Wang, Yi, Chen, Tianhong, Li, Hanke, Hu, Yingkun, Feng, Qinyu, Li, Jingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582762/
https://www.ncbi.nlm.nih.gov/pubmed/36277377
http://dx.doi.org/10.3389/fbioe.2022.1030162
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author Hao, Zhuowen
Chen, Renxin
Chai, Chen
Wang, Yi
Chen, Tianhong
Li, Hanke
Hu, Yingkun
Feng, Qinyu
Li, Jingfeng
author_facet Hao, Zhuowen
Chen, Renxin
Chai, Chen
Wang, Yi
Chen, Tianhong
Li, Hanke
Hu, Yingkun
Feng, Qinyu
Li, Jingfeng
author_sort Hao, Zhuowen
collection PubMed
description Bone tissue engineering has been becoming a promising strategy for surgical bone repair, but the risk of infection during trauma repair remains a problematic health concern worldwide, especially for fracture and infection-caused bone defects. Conventional antibiotics fail to effectively prevent or treat bone infections during bone defect repair because of drug-resistance and recurrence, so novel antibacterial agents with limited resistance are highly needed for bone tissue engineering. Antimicrobial peptides (AMPs) characterized by cationic, hydrophobic and amphipathic properties show great promise to be used as next-generation antibiotics which rarely induce resistance and show potent antibacterial efficacy. In this review, four common structures of AMPs (helix-based, sheet-based, coil-based and composite) and related modifications are presented to identify AMPs and design novel analogs. Then, potential effects of AMPs for bone infection during bone repair are explored, including bactericidal activity, anti-biofilm, immunomodulation and regenerative properties. Moreover, we present distinctive applications of AMPs for topical bone repair, which can be either used by delivery system (surface immobilization, nanoparticles and hydrogels) or used in gene therapy. Finally, future prospects and ongoing challenges are discussed.
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spelling pubmed-95827622022-10-21 Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications Hao, Zhuowen Chen, Renxin Chai, Chen Wang, Yi Chen, Tianhong Li, Hanke Hu, Yingkun Feng, Qinyu Li, Jingfeng Front Bioeng Biotechnol Bioengineering and Biotechnology Bone tissue engineering has been becoming a promising strategy for surgical bone repair, but the risk of infection during trauma repair remains a problematic health concern worldwide, especially for fracture and infection-caused bone defects. Conventional antibiotics fail to effectively prevent or treat bone infections during bone defect repair because of drug-resistance and recurrence, so novel antibacterial agents with limited resistance are highly needed for bone tissue engineering. Antimicrobial peptides (AMPs) characterized by cationic, hydrophobic and amphipathic properties show great promise to be used as next-generation antibiotics which rarely induce resistance and show potent antibacterial efficacy. In this review, four common structures of AMPs (helix-based, sheet-based, coil-based and composite) and related modifications are presented to identify AMPs and design novel analogs. Then, potential effects of AMPs for bone infection during bone repair are explored, including bactericidal activity, anti-biofilm, immunomodulation and regenerative properties. Moreover, we present distinctive applications of AMPs for topical bone repair, which can be either used by delivery system (surface immobilization, nanoparticles and hydrogels) or used in gene therapy. Finally, future prospects and ongoing challenges are discussed. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9582762/ /pubmed/36277377 http://dx.doi.org/10.3389/fbioe.2022.1030162 Text en Copyright © 2022 Hao, Chen, Chai, Wang, Chen, Li, Hu, Feng and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Hao, Zhuowen
Chen, Renxin
Chai, Chen
Wang, Yi
Chen, Tianhong
Li, Hanke
Hu, Yingkun
Feng, Qinyu
Li, Jingfeng
Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications
title Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications
title_full Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications
title_fullStr Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications
title_full_unstemmed Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications
title_short Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications
title_sort antimicrobial peptides for bone tissue engineering: diversity, effects and applications
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582762/
https://www.ncbi.nlm.nih.gov/pubmed/36277377
http://dx.doi.org/10.3389/fbioe.2022.1030162
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