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Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice

Oxidation of BH(4), a cofactor of nitric oxide synthase (NOS), produces reactive oxygen species (ROS) through uncoupling of NOS and affects vascular endothelial dysfunction. Ascorbic acid (AsA) inhibits the oxidation of BH(4) and reduces ROS. However, the kinetic changes of BH(4) in sepsis and its e...

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Detalles Bibliográficos
Autores principales:	Madokoro, Yutaro, Kamikokuryo, Chinatsu, Niiyama, Shuhei, Ito, Takashi, Hara, Satoshi, Ichinose, Hiroshi, Kakihana, Yasuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582851/ https://www.ncbi.nlm.nih.gov/pubmed/36278212 http://dx.doi.org/10.3389/fphar.2022.929448

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