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Transmission electron microscopy of pili annulati()
BACKGROUND: Little is known about the ultrastructure of pili annulati. OBJECTIVES: To examine with transmission electron microscopy affected hairs of a family, whose diagnosis had been confirmed in five individuals with scanning electron microscopy, which showed surface undulations with “curtain-lik...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582873/ https://www.ncbi.nlm.nih.gov/pubmed/36100477 http://dx.doi.org/10.1016/j.abd.2021.10.011 |
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author | Pinto, Joice Brião Göebel de Almeida, Hiram Larangeira de Almeida, Antônia Larangeira Firpo, Pedro de Oliveira |
author_facet | Pinto, Joice Brião Göebel de Almeida, Hiram Larangeira de Almeida, Antônia Larangeira Firpo, Pedro de Oliveira |
author_sort | Pinto, Joice Brião Göebel |
collection | PubMed |
description | BACKGROUND: Little is known about the ultrastructure of pili annulati. OBJECTIVES: To examine with transmission electron microscopy affected hairs of a family, whose diagnosis had been confirmed in five individuals with scanning electron microscopy, which showed surface undulations with “curtain-like” folding of the hair cuticula and to compare the findings with normal control. METHODS: Hairs of two affected patients and one control were embedded in resin and cut lengthwise to produce ultra-thin sections. RESULTS: The normal hair showed a parallel arrangement of dark lines associated with less electron-dense wide bands. Small cavities could be observed, mostly in the dark lines, affected hairs had a large number of cavities, associated or not with the insertion of melanosomes and loss of parallelism of the dark lines. Higher magnification showed a significant loss of this parallelism, resembling “wood grooves”. Widened dark lines were observed in some areas. STUDY LIMITATIONS: Only a few hairs were examined. CONCLUSIONS: The present results suggest that the microcanaliculi of the hair surface, easily found with scanning electron microscopy, may be secondary not only to the cavities seen in the sections but also to the disorder of proteins that form this region, demonstrated by the changes of the cortex dark lines. |
format | Online Article Text |
id | pubmed-9582873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-95828732022-10-20 Transmission electron microscopy of pili annulati() Pinto, Joice Brião Göebel de Almeida, Hiram Larangeira de Almeida, Antônia Larangeira Firpo, Pedro de Oliveira An Bras Dermatol Original Article BACKGROUND: Little is known about the ultrastructure of pili annulati. OBJECTIVES: To examine with transmission electron microscopy affected hairs of a family, whose diagnosis had been confirmed in five individuals with scanning electron microscopy, which showed surface undulations with “curtain-like” folding of the hair cuticula and to compare the findings with normal control. METHODS: Hairs of two affected patients and one control were embedded in resin and cut lengthwise to produce ultra-thin sections. RESULTS: The normal hair showed a parallel arrangement of dark lines associated with less electron-dense wide bands. Small cavities could be observed, mostly in the dark lines, affected hairs had a large number of cavities, associated or not with the insertion of melanosomes and loss of parallelism of the dark lines. Higher magnification showed a significant loss of this parallelism, resembling “wood grooves”. Widened dark lines were observed in some areas. STUDY LIMITATIONS: Only a few hairs were examined. CONCLUSIONS: The present results suggest that the microcanaliculi of the hair surface, easily found with scanning electron microscopy, may be secondary not only to the cavities seen in the sections but also to the disorder of proteins that form this region, demonstrated by the changes of the cortex dark lines. Sociedade Brasileira de Dermatologia 2022 2022-09-10 /pmc/articles/PMC9582873/ /pubmed/36100477 http://dx.doi.org/10.1016/j.abd.2021.10.011 Text en © 2022 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Pinto, Joice Brião Göebel de Almeida, Hiram Larangeira de Almeida, Antônia Larangeira Firpo, Pedro de Oliveira Transmission electron microscopy of pili annulati() |
title | Transmission electron microscopy of pili annulati() |
title_full | Transmission electron microscopy of pili annulati() |
title_fullStr | Transmission electron microscopy of pili annulati() |
title_full_unstemmed | Transmission electron microscopy of pili annulati() |
title_short | Transmission electron microscopy of pili annulati() |
title_sort | transmission electron microscopy of pili annulati() |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582873/ https://www.ncbi.nlm.nih.gov/pubmed/36100477 http://dx.doi.org/10.1016/j.abd.2021.10.011 |
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