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The skin through reflectance confocal microscopy — Historical background, technical principles, and its correlation with histopathology()

Since its first introduction into medical practice, reflectance confocal microscopy (RCM) has been a valuable non-invasive diagnostic tool for the assessment of benign and malignant neoplasms of the skin. It has also been used as an adjunct for diagnosing equivocal cutaneous neoplasms that lack char...

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Autores principales: Braghiroli, Naiara Fraga, Sugerik, Samantha, Freitas, Luiz Antônio Rodrigues de, Oliviero, Margaret, Rabinovitz, Harold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582891/
https://www.ncbi.nlm.nih.gov/pubmed/36153173
http://dx.doi.org/10.1016/j.abd.2021.10.010
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author Braghiroli, Naiara Fraga
Sugerik, Samantha
Freitas, Luiz Antônio Rodrigues de
Oliviero, Margaret
Rabinovitz, Harold
author_facet Braghiroli, Naiara Fraga
Sugerik, Samantha
Freitas, Luiz Antônio Rodrigues de
Oliviero, Margaret
Rabinovitz, Harold
author_sort Braghiroli, Naiara Fraga
collection PubMed
description Since its first introduction into medical practice, reflectance confocal microscopy (RCM) has been a valuable non-invasive diagnostic tool for the assessment of benign and malignant neoplasms of the skin. It has also been used as an adjunct for diagnosing equivocal cutaneous neoplasms that lack characteristic clinical or dermoscopic features. The use of RCM has led to a decreased number of biopsies of benign lesions. Multiple published studies show a strong correlation between RCM and histopathology thereby creating a bridge between clinical aspects, dermoscopy, and histopathology. Dermatopathologists may potentially play an important role in the interpretation of confocal images, by their ability to correlate histopathologic findings. RCM has also been shown to be an important adjunct to delineating tumoral margins during surgery, as well as for monitoring the non-surgical treatment of skin cancers. Advanced technology with smaller probes, such as the VivaScope 3000, has allowed access to lesions in previously inaccessible anatomic locations. This review explains the technical principles of RCM and describes the most common RCM features of normal skin with their corresponding histological correlation.
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spelling pubmed-95828912022-10-20 The skin through reflectance confocal microscopy — Historical background, technical principles, and its correlation with histopathology() Braghiroli, Naiara Fraga Sugerik, Samantha Freitas, Luiz Antônio Rodrigues de Oliviero, Margaret Rabinovitz, Harold An Bras Dermatol Continuing Medical Education Since its first introduction into medical practice, reflectance confocal microscopy (RCM) has been a valuable non-invasive diagnostic tool for the assessment of benign and malignant neoplasms of the skin. It has also been used as an adjunct for diagnosing equivocal cutaneous neoplasms that lack characteristic clinical or dermoscopic features. The use of RCM has led to a decreased number of biopsies of benign lesions. Multiple published studies show a strong correlation between RCM and histopathology thereby creating a bridge between clinical aspects, dermoscopy, and histopathology. Dermatopathologists may potentially play an important role in the interpretation of confocal images, by their ability to correlate histopathologic findings. RCM has also been shown to be an important adjunct to delineating tumoral margins during surgery, as well as for monitoring the non-surgical treatment of skin cancers. Advanced technology with smaller probes, such as the VivaScope 3000, has allowed access to lesions in previously inaccessible anatomic locations. This review explains the technical principles of RCM and describes the most common RCM features of normal skin with their corresponding histological correlation. Sociedade Brasileira de Dermatologia 2022 2022-09-21 /pmc/articles/PMC9582891/ /pubmed/36153173 http://dx.doi.org/10.1016/j.abd.2021.10.010 Text en © 2022 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Continuing Medical Education
Braghiroli, Naiara Fraga
Sugerik, Samantha
Freitas, Luiz Antônio Rodrigues de
Oliviero, Margaret
Rabinovitz, Harold
The skin through reflectance confocal microscopy — Historical background, technical principles, and its correlation with histopathology()
title The skin through reflectance confocal microscopy — Historical background, technical principles, and its correlation with histopathology()
title_full The skin through reflectance confocal microscopy — Historical background, technical principles, and its correlation with histopathology()
title_fullStr The skin through reflectance confocal microscopy — Historical background, technical principles, and its correlation with histopathology()
title_full_unstemmed The skin through reflectance confocal microscopy — Historical background, technical principles, and its correlation with histopathology()
title_short The skin through reflectance confocal microscopy — Historical background, technical principles, and its correlation with histopathology()
title_sort skin through reflectance confocal microscopy — historical background, technical principles, and its correlation with histopathology()
topic Continuing Medical Education
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582891/
https://www.ncbi.nlm.nih.gov/pubmed/36153173
http://dx.doi.org/10.1016/j.abd.2021.10.010
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