Cargando…

Prevalence of proximate risk factors of active tuberculosis in latent tuberculosis infection: A cross-sectional study from South India

The prevalence of proximate risk factors for active tuberculosis (TB) in areas of high prevalence of latent tuberculosis infection (LTBI) is not clearly understood. We aimed at assessing the prevalence of non-communicable multi-morbidity focusing on diabetes mellitus (DM), malnutrition, and hyperten...

Descripción completa

Detalles Bibliográficos
Autores principales: Munisankar, Saravanan, Rajamanickam, Anuradha, Balasubramanian, Suganthi, Muthusamy, Satishwaran, Menon, Pradeep Aravindan, Ahamed, Shaik Fayaz, Whalen, Christopher, Gumne, Paschaline, Kaur, Inderdeep, Nadimpalli, Varma, Deverakonda, Akshay, Chen, Zhenhao, Otto, John David, Habitegiyorgis, Tesfalidet, Kandaswamy, Harish, Babu, Subash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583021/
https://www.ncbi.nlm.nih.gov/pubmed/36276400
http://dx.doi.org/10.3389/fpubh.2022.1011388
_version_ 1784812975737012224
author Munisankar, Saravanan
Rajamanickam, Anuradha
Balasubramanian, Suganthi
Muthusamy, Satishwaran
Menon, Pradeep Aravindan
Ahamed, Shaik Fayaz
Whalen, Christopher
Gumne, Paschaline
Kaur, Inderdeep
Nadimpalli, Varma
Deverakonda, Akshay
Chen, Zhenhao
Otto, John David
Habitegiyorgis, Tesfalidet
Kandaswamy, Harish
Babu, Subash
author_facet Munisankar, Saravanan
Rajamanickam, Anuradha
Balasubramanian, Suganthi
Muthusamy, Satishwaran
Menon, Pradeep Aravindan
Ahamed, Shaik Fayaz
Whalen, Christopher
Gumne, Paschaline
Kaur, Inderdeep
Nadimpalli, Varma
Deverakonda, Akshay
Chen, Zhenhao
Otto, John David
Habitegiyorgis, Tesfalidet
Kandaswamy, Harish
Babu, Subash
author_sort Munisankar, Saravanan
collection PubMed
description The prevalence of proximate risk factors for active tuberculosis (TB) in areas of high prevalence of latent tuberculosis infection (LTBI) is not clearly understood. We aimed at assessing the prevalence of non-communicable multi-morbidity focusing on diabetes mellitus (DM), malnutrition, and hypertension (HTN) as common risk factors of LTBI progressing to active TB. In a cross-sectional study, 2,351 adults (45% male and 55% female) from villages in the Kancheepuram district of South India were enrolled between 2013 and 2020. DM was defined as HbA1c >6.4%, undernutrition was defined as low body mass index (LBMI) <18.5 kg/m(2), obesity was classified as BMI ≥25 kg/m(2), HTN was reported as systolic pressure >130 mmHg, and LTBI was defined as positive (≥ 0.35 international units/ml) by QuantiFERON Gold In-Tube assay. A total of 1,226 individuals (52%) were positive for LTBI out of 2351 tested individuals. The prevalence of DM and pre-diabetes mellitus (PDM) was 21 and 35%, respectively, HTN was 15% in latent tuberculosis (LTB)-infected individuals. The association of DM [odds ratio (OR)]; adjusted odds ratio (aOR) (OR = 1.26, 95% CI: 1.13–1.65; aOR = 1.19, 95% CI: 1.10–1.58), PDM (OR = 1.11, 95% CI: 1.0–1.35), and HTN (OR = 1.28, 95% CI: 1.11–1.62; aOR = 1.18, 95% CI: 1.0–1.56) poses as risk factors of LTBI progression to active TB. The prevalence of LBMI 9% (OR = 1.07, 95% CI: 0.78–1.48) and obesity 42% (OR = 0.85, 95% CI: 0.70–1.03) did not show any statistically significant association with LTB-infected individuals. The present evidence of a high burden of multi-morbidity suggests that proximate risk factors of active TB in LTBI can be managed by nutrition and lifestyle modification.
format Online
Article
Text
id pubmed-9583021
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95830212022-10-21 Prevalence of proximate risk factors of active tuberculosis in latent tuberculosis infection: A cross-sectional study from South India Munisankar, Saravanan Rajamanickam, Anuradha Balasubramanian, Suganthi Muthusamy, Satishwaran Menon, Pradeep Aravindan Ahamed, Shaik Fayaz Whalen, Christopher Gumne, Paschaline Kaur, Inderdeep Nadimpalli, Varma Deverakonda, Akshay Chen, Zhenhao Otto, John David Habitegiyorgis, Tesfalidet Kandaswamy, Harish Babu, Subash Front Public Health Public Health The prevalence of proximate risk factors for active tuberculosis (TB) in areas of high prevalence of latent tuberculosis infection (LTBI) is not clearly understood. We aimed at assessing the prevalence of non-communicable multi-morbidity focusing on diabetes mellitus (DM), malnutrition, and hypertension (HTN) as common risk factors of LTBI progressing to active TB. In a cross-sectional study, 2,351 adults (45% male and 55% female) from villages in the Kancheepuram district of South India were enrolled between 2013 and 2020. DM was defined as HbA1c >6.4%, undernutrition was defined as low body mass index (LBMI) <18.5 kg/m(2), obesity was classified as BMI ≥25 kg/m(2), HTN was reported as systolic pressure >130 mmHg, and LTBI was defined as positive (≥ 0.35 international units/ml) by QuantiFERON Gold In-Tube assay. A total of 1,226 individuals (52%) were positive for LTBI out of 2351 tested individuals. The prevalence of DM and pre-diabetes mellitus (PDM) was 21 and 35%, respectively, HTN was 15% in latent tuberculosis (LTB)-infected individuals. The association of DM [odds ratio (OR)]; adjusted odds ratio (aOR) (OR = 1.26, 95% CI: 1.13–1.65; aOR = 1.19, 95% CI: 1.10–1.58), PDM (OR = 1.11, 95% CI: 1.0–1.35), and HTN (OR = 1.28, 95% CI: 1.11–1.62; aOR = 1.18, 95% CI: 1.0–1.56) poses as risk factors of LTBI progression to active TB. The prevalence of LBMI 9% (OR = 1.07, 95% CI: 0.78–1.48) and obesity 42% (OR = 0.85, 95% CI: 0.70–1.03) did not show any statistically significant association with LTB-infected individuals. The present evidence of a high burden of multi-morbidity suggests that proximate risk factors of active TB in LTBI can be managed by nutrition and lifestyle modification. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9583021/ /pubmed/36276400 http://dx.doi.org/10.3389/fpubh.2022.1011388 Text en Copyright © 2022 Munisankar, Rajamanickam, Balasubramanian, Muthusamy, Menon, Ahamed, Whalen, Gumne, Kaur, Nadimpalli, Deverakonda, Chen, Otto, Habitegiyorgis, Kandaswamy and Babu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Munisankar, Saravanan
Rajamanickam, Anuradha
Balasubramanian, Suganthi
Muthusamy, Satishwaran
Menon, Pradeep Aravindan
Ahamed, Shaik Fayaz
Whalen, Christopher
Gumne, Paschaline
Kaur, Inderdeep
Nadimpalli, Varma
Deverakonda, Akshay
Chen, Zhenhao
Otto, John David
Habitegiyorgis, Tesfalidet
Kandaswamy, Harish
Babu, Subash
Prevalence of proximate risk factors of active tuberculosis in latent tuberculosis infection: A cross-sectional study from South India
title Prevalence of proximate risk factors of active tuberculosis in latent tuberculosis infection: A cross-sectional study from South India
title_full Prevalence of proximate risk factors of active tuberculosis in latent tuberculosis infection: A cross-sectional study from South India
title_fullStr Prevalence of proximate risk factors of active tuberculosis in latent tuberculosis infection: A cross-sectional study from South India
title_full_unstemmed Prevalence of proximate risk factors of active tuberculosis in latent tuberculosis infection: A cross-sectional study from South India
title_short Prevalence of proximate risk factors of active tuberculosis in latent tuberculosis infection: A cross-sectional study from South India
title_sort prevalence of proximate risk factors of active tuberculosis in latent tuberculosis infection: a cross-sectional study from south india
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583021/
https://www.ncbi.nlm.nih.gov/pubmed/36276400
http://dx.doi.org/10.3389/fpubh.2022.1011388
work_keys_str_mv AT munisankarsaravanan prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT rajamanickamanuradha prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT balasubramaniansuganthi prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT muthusamysatishwaran prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT menonpradeeparavindan prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT ahamedshaikfayaz prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT whalenchristopher prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT gumnepaschaline prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT kaurinderdeep prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT nadimpallivarma prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT deverakondaakshay prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT chenzhenhao prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT ottojohndavid prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT habitegiyorgistesfalidet prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT kandaswamyharish prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia
AT babusubash prevalenceofproximateriskfactorsofactivetuberculosisinlatenttuberculosisinfectionacrosssectionalstudyfromsouthindia