Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16

• A stable EV-A71 virus vector was created to generate chimeric strains expressing capsid protein genes of EV-A71 C5 and CA16. • Phenotypic and genetic stability of the generated chimeric EV-A71 and CA16 were analyzed. • The amino acids at the cleavage site between VP1 and 2A is crucial for stabilit...

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Detalles Bibliográficos
Autores principales: Chua, Kaw Bing, Ng, Qimei, Meng, Tao, Jia, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583105/
https://www.ncbi.nlm.nih.gov/pubmed/35964922
http://dx.doi.org/10.1016/j.virs.2022.08.001
Descripción
Sumario:• A stable EV-A71 virus vector was created to generate chimeric strains expressing capsid protein genes of EV-A71 C5 and CA16. • Phenotypic and genetic stability of the generated chimeric EV-A71 and CA16 were analyzed. • The amino acids at the cleavage site between VP1 and 2A is crucial for stability.

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