Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16

• A stable EV-A71 virus vector was created to generate chimeric strains expressing capsid protein genes of EV-A71 C5 and CA16. • Phenotypic and genetic stability of the generated chimeric EV-A71 and CA16 were analyzed. • The amino acids at the cleavage site between VP1 and 2A is crucial for stabilit...

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Autores principales: Chua, Kaw Bing, Ng, Qimei, Meng, Tao, Jia, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583105/
https://www.ncbi.nlm.nih.gov/pubmed/35964922
http://dx.doi.org/10.1016/j.virs.2022.08.001
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author Chua, Kaw Bing
Ng, Qimei
Meng, Tao
Jia, Qiang
author_facet Chua, Kaw Bing
Ng, Qimei
Meng, Tao
Jia, Qiang
author_sort Chua, Kaw Bing
collection PubMed
description • A stable EV-A71 virus vector was created to generate chimeric strains expressing capsid protein genes of EV-A71 C5 and CA16. • Phenotypic and genetic stability of the generated chimeric EV-A71 and CA16 were analyzed. • The amino acids at the cleavage site between VP1 and 2A is crucial for stability.
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spelling pubmed-95831052022-10-20 Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16 Chua, Kaw Bing Ng, Qimei Meng, Tao Jia, Qiang Virol Sin Letter • A stable EV-A71 virus vector was created to generate chimeric strains expressing capsid protein genes of EV-A71 C5 and CA16. • Phenotypic and genetic stability of the generated chimeric EV-A71 and CA16 were analyzed. • The amino acids at the cleavage site between VP1 and 2A is crucial for stability. Wuhan Institute of Virology, Chinese Academy of Sciences 2022-08-11 /pmc/articles/PMC9583105/ /pubmed/35964922 http://dx.doi.org/10.1016/j.virs.2022.08.001 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letter
Chua, Kaw Bing
Ng, Qimei
Meng, Tao
Jia, Qiang
Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16
title Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16
title_full Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16
title_fullStr Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16
title_full_unstemmed Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16
title_short Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16
title_sort development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus a71 and coxsackievirus a16
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583105/
https://www.ncbi.nlm.nih.gov/pubmed/35964922
http://dx.doi.org/10.1016/j.virs.2022.08.001
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