Variable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization

[Image: see text] The synthesis with structural identifications including NMR and HRMS spectral data along with single-crystal X-ray diffraction analysis (for 20b, 23b, 25b–27b) of a family of 14 new syn/anti bis-4-spiro-β-lactam-based unsaturated macrocycles (19a,b–27a,b), obtained by multistep syn...

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Detalles Bibliográficos
Autores principales: Mohamed, Asaad S., Al-Awadhi, Fatma H., Al-Awadi, Nouria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583306/
https://www.ncbi.nlm.nih.gov/pubmed/36278047
http://dx.doi.org/10.1021/acsomega.2c05212
Descripción
Sumario:[Image: see text] The synthesis with structural identifications including NMR and HRMS spectral data along with single-crystal X-ray diffraction analysis (for 20b, 23b, 25b–27b) of a family of 14 new syn/anti bis-4-spiro-β-lactam-based unsaturated macrocycles (19a,b–27a,b), obtained by multistep synthesis including (i) diimine formation, (ii) Staudinger [2 + 2] ketene–imine cycloaddition, and (iii) ring-closing metathesis (RCM), is reported.

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