Variable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization

[Image: see text] The synthesis with structural identifications including NMR and HRMS spectral data along with single-crystal X-ray diffraction analysis (for 20b, 23b, 25b–27b) of a family of 14 new syn/anti bis-4-spiro-β-lactam-based unsaturated macrocycles (19a,b–27a,b), obtained by multistep syn...

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Autores principales: Mohamed, Asaad S., Al-Awadhi, Fatma H., Al-Awadi, Nouria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583306/
https://www.ncbi.nlm.nih.gov/pubmed/36278047
http://dx.doi.org/10.1021/acsomega.2c05212
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author Mohamed, Asaad S.
Al-Awadhi, Fatma H.
Al-Awadi, Nouria A.
author_facet Mohamed, Asaad S.
Al-Awadhi, Fatma H.
Al-Awadi, Nouria A.
author_sort Mohamed, Asaad S.
collection PubMed
description [Image: see text] The synthesis with structural identifications including NMR and HRMS spectral data along with single-crystal X-ray diffraction analysis (for 20b, 23b, 25b–27b) of a family of 14 new syn/anti bis-4-spiro-β-lactam-based unsaturated macrocycles (19a,b–27a,b), obtained by multistep synthesis including (i) diimine formation, (ii) Staudinger [2 + 2] ketene–imine cycloaddition, and (iii) ring-closing metathesis (RCM), is reported.
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spelling pubmed-95833062022-10-21 Variable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization Mohamed, Asaad S. Al-Awadhi, Fatma H. Al-Awadi, Nouria A. ACS Omega [Image: see text] The synthesis with structural identifications including NMR and HRMS spectral data along with single-crystal X-ray diffraction analysis (for 20b, 23b, 25b–27b) of a family of 14 new syn/anti bis-4-spiro-β-lactam-based unsaturated macrocycles (19a,b–27a,b), obtained by multistep synthesis including (i) diimine formation, (ii) Staudinger [2 + 2] ketene–imine cycloaddition, and (iii) ring-closing metathesis (RCM), is reported. American Chemical Society 2022-10-04 /pmc/articles/PMC9583306/ /pubmed/36278047 http://dx.doi.org/10.1021/acsomega.2c05212 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mohamed, Asaad S.
Al-Awadhi, Fatma H.
Al-Awadi, Nouria A.
Variable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization
title Variable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization
title_full Variable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization
title_fullStr Variable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization
title_full_unstemmed Variable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization
title_short Variable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization
title_sort variable-sized bis(4-spiro-fused-β-lactam)-based unsaturated macrocycles: synthesis and characterization
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583306/
https://www.ncbi.nlm.nih.gov/pubmed/36278047
http://dx.doi.org/10.1021/acsomega.2c05212
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