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Vitamin D status in Psoriasis: impact and clinical correlations

Psoriasis is a continuing, periodic, immune‑mediated, fiery skin disease branded by hyper proliferation of epidermal keratinocytes and accompanying with inflammatory cellular infiltrate in both dermis and epidermis. Immunomodulation could be an important effect of vitamin D in Psoriasis. This case-c...

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Autores principales: Bhat, Ghulam Hassan, Guldin, Sadaf, Khan, Mosin Saleem, Yasir, Mir, Prasad, Ganesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583481/
https://www.ncbi.nlm.nih.gov/pubmed/36261848
http://dx.doi.org/10.1186/s40795-022-00610-y
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author Bhat, Ghulam Hassan
Guldin, Sadaf
Khan, Mosin Saleem
Yasir, Mir
Prasad, Ganesh
author_facet Bhat, Ghulam Hassan
Guldin, Sadaf
Khan, Mosin Saleem
Yasir, Mir
Prasad, Ganesh
author_sort Bhat, Ghulam Hassan
collection PubMed
description Psoriasis is a continuing, periodic, immune‑mediated, fiery skin disease branded by hyper proliferation of epidermal keratinocytes and accompanying with inflammatory cellular infiltrate in both dermis and epidermis. Immunomodulation could be an important effect of vitamin D in Psoriasis. This case-control study was designed to measure serum 25-hydroxy vitamin D levels in patients with psoriasis and healthy controls and to find out clinical correlation, if any. Six hundred two (n = 602) subjects (285 cases and 317 controls) were taken for the study. Cases and controls were frequency matched with respect to age and gender. Various demographic and clinical details were taken using a questionnaire. Chemiluminescence Micro Particle Immunoassay was used to estimate serum 25-hydroxy vitamin D levels. The vitamin D deficiency in psoriasis patients was 60.0% vs. 17.5% in controls (P < 0.001) with mean vitamin D levels of 28.3 ± 13.9 ng/ml in psoriasis patient’s vs. 37.9 ± 9.7 ng/ml in controls. Vitamin D deficiency was found to be associated with psoriasis independently of gender, age, smoking status, family history, hypertension, chronic medication, nail changes, duration of symptoms and severity of disease. Vitamin D levels were seven times lower in patients with Psoriasis as compared to controls. Reduced vitamin D levels are related to duration and clinical severity of the disease. Early detection of vitamin D deficiency and timely intervention could lead to better clinical outcome and improved quality of life in psoriasis patients.
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spelling pubmed-95834812022-10-21 Vitamin D status in Psoriasis: impact and clinical correlations Bhat, Ghulam Hassan Guldin, Sadaf Khan, Mosin Saleem Yasir, Mir Prasad, Ganesh BMC Nutr Research Psoriasis is a continuing, periodic, immune‑mediated, fiery skin disease branded by hyper proliferation of epidermal keratinocytes and accompanying with inflammatory cellular infiltrate in both dermis and epidermis. Immunomodulation could be an important effect of vitamin D in Psoriasis. This case-control study was designed to measure serum 25-hydroxy vitamin D levels in patients with psoriasis and healthy controls and to find out clinical correlation, if any. Six hundred two (n = 602) subjects (285 cases and 317 controls) were taken for the study. Cases and controls were frequency matched with respect to age and gender. Various demographic and clinical details were taken using a questionnaire. Chemiluminescence Micro Particle Immunoassay was used to estimate serum 25-hydroxy vitamin D levels. The vitamin D deficiency in psoriasis patients was 60.0% vs. 17.5% in controls (P < 0.001) with mean vitamin D levels of 28.3 ± 13.9 ng/ml in psoriasis patient’s vs. 37.9 ± 9.7 ng/ml in controls. Vitamin D deficiency was found to be associated with psoriasis independently of gender, age, smoking status, family history, hypertension, chronic medication, nail changes, duration of symptoms and severity of disease. Vitamin D levels were seven times lower in patients with Psoriasis as compared to controls. Reduced vitamin D levels are related to duration and clinical severity of the disease. Early detection of vitamin D deficiency and timely intervention could lead to better clinical outcome and improved quality of life in psoriasis patients. BioMed Central 2022-10-19 /pmc/articles/PMC9583481/ /pubmed/36261848 http://dx.doi.org/10.1186/s40795-022-00610-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Bhat, Ghulam Hassan
Guldin, Sadaf
Khan, Mosin Saleem
Yasir, Mir
Prasad, Ganesh
Vitamin D status in Psoriasis: impact and clinical correlations
title Vitamin D status in Psoriasis: impact and clinical correlations
title_full Vitamin D status in Psoriasis: impact and clinical correlations
title_fullStr Vitamin D status in Psoriasis: impact and clinical correlations
title_full_unstemmed Vitamin D status in Psoriasis: impact and clinical correlations
title_short Vitamin D status in Psoriasis: impact and clinical correlations
title_sort vitamin d status in psoriasis: impact and clinical correlations
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583481/
https://www.ncbi.nlm.nih.gov/pubmed/36261848
http://dx.doi.org/10.1186/s40795-022-00610-y
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