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AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo

BACKGROUND: Uncoupling protein 2 (UCP2), activated by excessive reactive oxygen species (ROS) in vivo, has the dual effect of reducing ROS to protect against oxidative stress and reducing ATP production to regulate cellular metabolism. Both the UCP2 and ROS are increased in cochleae in age-related h...

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Detalles Bibliográficos
Autores principales:	Zhao, Chunli, Yang, Zijing, Chen, Zhongrui, Liang, Wenqi, Gong, Shusheng, Du, Zhengde
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583487/ https://www.ncbi.nlm.nih.gov/pubmed/36266633 http://dx.doi.org/10.1186/s10020-022-00552-y

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