An NADPH sensor that regulates cell ferroptosis

Ferroptosis is a new form of programmed cell death, which achieved great breakthroughs in cell biology during past decade. However, the regulation of ferroptosis is yet to be identified thoroughly. The latest study published on Nature cell biology by Nguyen and colleagues found a new NADPH sensor, M...

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Autores principales: Kuang, Guixing, Wang, Weidong, Xiong, Dan, Zeng, Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583509/
https://www.ncbi.nlm.nih.gov/pubmed/36266653
http://dx.doi.org/10.1186/s12967-022-03658-3
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author Kuang, Guixing
Wang, Weidong
Xiong, Dan
Zeng, Chong
author_facet Kuang, Guixing
Wang, Weidong
Xiong, Dan
Zeng, Chong
author_sort Kuang, Guixing
collection PubMed
description Ferroptosis is a new form of programmed cell death, which achieved great breakthroughs in cell biology during past decade. However, the regulation of ferroptosis is yet to be identified thoroughly. The latest study published on Nature cell biology by Nguyen and colleagues found a new NADPH sensor, MARCHF6 an E3 ubiquitin ligase, mediates ferroptosis in tumor growth and animal development. This finding provides a novel insight into ubiquitin system and energy metabolism in regulation of ferroptosis, which may open up new avenues for tumor treatment.
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spelling pubmed-95835092022-10-21 An NADPH sensor that regulates cell ferroptosis Kuang, Guixing Wang, Weidong Xiong, Dan Zeng, Chong J Transl Med Commentary Ferroptosis is a new form of programmed cell death, which achieved great breakthroughs in cell biology during past decade. However, the regulation of ferroptosis is yet to be identified thoroughly. The latest study published on Nature cell biology by Nguyen and colleagues found a new NADPH sensor, MARCHF6 an E3 ubiquitin ligase, mediates ferroptosis in tumor growth and animal development. This finding provides a novel insight into ubiquitin system and energy metabolism in regulation of ferroptosis, which may open up new avenues for tumor treatment. BioMed Central 2022-10-20 /pmc/articles/PMC9583509/ /pubmed/36266653 http://dx.doi.org/10.1186/s12967-022-03658-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Kuang, Guixing
Wang, Weidong
Xiong, Dan
Zeng, Chong
An NADPH sensor that regulates cell ferroptosis
title An NADPH sensor that regulates cell ferroptosis
title_full An NADPH sensor that regulates cell ferroptosis
title_fullStr An NADPH sensor that regulates cell ferroptosis
title_full_unstemmed An NADPH sensor that regulates cell ferroptosis
title_short An NADPH sensor that regulates cell ferroptosis
title_sort nadph sensor that regulates cell ferroptosis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583509/
https://www.ncbi.nlm.nih.gov/pubmed/36266653
http://dx.doi.org/10.1186/s12967-022-03658-3
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