Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses

BACKGROUND: A major driver of cancer chromosomal instability is replication stress, the slowing or stalling of DNA replication. How replication stress and genomic instability are connected is not known. Aphidicolin-induced replication stress induces breakages at common fragile sites, but the exact c...

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Detalles Bibliográficos
Autores principales: Shaikh, Nadeem, Mazzagatti, Alice, De Angelis, Simone, Johnson, Sarah C., Bakker, Bjorn, Spierings, Diana C. J., Wardenaar, René, Maniati, Eleni, Wang, Jun, Boemo, Michael A., Foijer, Floris, McClelland, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583511/
https://www.ncbi.nlm.nih.gov/pubmed/36266663
http://dx.doi.org/10.1186/s13059-022-02781-0

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